Life at the margins

Modulation of attachment proteins in Helicobacter pylori

Mary E. Moore, Thomas Borén, Jay V Solnick

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Helicobacter pylori is the primary cause of peptic ulcer disease and is estimated to account for about 60% of all cases of gastric cancer, the second most common cause of cancer death worldwide. Among the H. pylori virulence factors associated with disease, in addition to the well-known cag pathogenicity island, is the BabA adhesin, an outer membrane protein that binds with high affinity to fucosylated glycans on the gastric epithelium, such as Lewis B (Leb) and related terminal fucose residues found on the blood group O (H antigen), A and B antigens. BabA-mediated attachment to the gastric mucosa promotes chronic inflammation and gastric pathology, which from the bacterial perspective carries both risks and benefits. We recently described modulation in expression of BabA and related outer membrane proteins that occurs during colonization of experimental animals.1,2 Here we put these findings into a broader context, and speculate on their implications for the host-pathogen relationship.

Original languageEnglish (US)
JournalGut Microbes
Volume2
Issue number1
DOIs
StatePublished - Jan 2011

Fingerprint

Helicobacter pylori
Stomach
Membrane Proteins
Genomic Islands
O Antigens
Fucose
Virulence Factors
Blood Group Antigens
Gastric Mucosa
Peptic Ulcer
Stomach Neoplasms
Polysaccharides
Cause of Death
Proteins
Epithelium
Pathology
Inflammation
Antigens
Neoplasms
H antigen

Keywords

  • Adhesion
  • Helicobacter pylori
  • Inflammation
  • Regulation

ASJC Scopus subject areas

  • Gastroenterology
  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology

Cite this

Life at the margins : Modulation of attachment proteins in Helicobacter pylori. / Moore, Mary E.; Borén, Thomas; Solnick, Jay V.

In: Gut Microbes, Vol. 2, No. 1, 01.2011.

Research output: Contribution to journalArticle

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