Life and death of immature neurons in the juvenile and adult primate amygdala

Loïc J. Chareyron, Pamela Banta Lavenex, David G. Amaral, Pierre Lavenex

Research output: Contribution to journalArticlepeer-review

Abstract

In recent years, a large population of immature neurons has been documented in the paralaminar nucleus of the primate amygdala. A substantial fraction of these immature neurons differentiate into mature neurons during postnatal development or following selective lesion of the hippocampus. Notwithstanding a growing number of studies on the origin and fate of these immature neurons, fundamental questions about the life and death of these neurons remain. Here, we briefly summarize what is currently known about the immature neurons present in the primate ventral amygdala during development and in adulthood, as well as following selective hippo-campal lesions. We provide evidence confirming that the distribution of immature neurons extends to the anterior portions of the entorhinal cortex and layer II of the perirhinal cortex. We also provide novel arguments derived from stereological estimates of the number of mature and immature neurons, which support the view that the migration of immature neurons from the lateral ventricle accompanies neuronal maturation in the primate amygdala at all ages. Finally, we propose and discuss the hypothesis that increased migration and maturation of neurons in the amygdala following hippocampal dysfunction may be linked to behavioral alterations associated with certain neurodevelopmental disorders.

Original languageEnglish (US)
Article number6691
JournalInternational journal of molecular sciences
Volume22
Issue number13
DOIs
StatePublished - Jul 1 2021

Keywords

  • Amygdala
  • Hippocampus
  • Lesion
  • Neuroblast
  • Neurode-velopmental disorders
  • Primate
  • Subventricular zone
  • Williams syndrome

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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