Abstract
Construction of synthetic combinatorial libraries is described that allows for the generation of a library of motifs rather than a library of compounds. Peptide libraries based on this strategy were synthesized and screened with model targets streptavidin and anti-β-endorphin antibody. The screens resulted in observation of expected motifs providing evidence of the effectiveness of the suggested approach.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5426-5430 |
| Number of pages | 5 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 92 |
| Issue number | 12 |
| State | Published - Jun 6 1995 |
| Externally published | Yes |
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ASJC Scopus subject areas
- General
- Genetics
Cite this
Sepetov, N. F., Krchňák, V., Stanková, M., Wade, S., Lam, K., & Lebl, M. (1995). Library of libraries: Approach to synthetic combinatorial library design and screening of "pharmacophore" motifs. Proceedings of the National Academy of Sciences of the United States of America, 92(12), 5426-5430.