Library of libraries: Approach to synthetic combinatorial library design and screening of "pharmacophore" motifs

Nikolai F. Sepetov, Viktor Krchňák, Magda Stanková, Shelly Wade, Kit Lam, Michal Lebl

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Construction of synthetic combinatorial libraries is described that allows for the generation of a library of motifs rather than a library of compounds. Peptide libraries based on this strategy were synthesized and screened with model targets streptavidin and anti-β-endorphin antibody. The screens resulted in observation of expected motifs providing evidence of the effectiveness of the suggested approach.

Original languageEnglish (US)
Pages (from-to)5426-5430
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume92
Issue number12
StatePublished - Jun 6 1995
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • General
  • Genetics

Cite this