Abstract
Construction of synthetic combinatorial libraries is described that allows for the generation of a library of motifs rather than a library of compounds. Peptide libraries based on this strategy were synthesized and screened with model targets streptavidin and anti-β-endorphin antibody. The screens resulted in observation of expected motifs providing evidence of the effectiveness of the suggested approach.
Original language | English (US) |
---|---|
Pages (from-to) | 5426-5430 |
Number of pages | 5 |
Journal | Proceedings of the National Academy of Sciences of the United States of America |
Volume | 92 |
Issue number | 12 |
State | Published - Jun 6 1995 |
Externally published | Yes |
ASJC Scopus subject areas
- General
- Genetics