Library of libraries: Approach to synthetic combinatorial library design and screening of "pharmacophore" motifs

Nikolai F. Sepetov; Viktor Krchňák; Magda Stanková; Shelly Wade; Kit Lam; Michal Lebl

Library of libraries: Approach to synthetic combinatorial library design and screening of "pharmacophore" motifs

Nikolai F. Sepetov, Viktor Krchňák, Magda Stanková, Shelly Wade, Kit Lam, Michal Lebl

Research output: Contribution to journal › Article › peer-review

Abstract

Construction of synthetic combinatorial libraries is described that allows for the generation of a library of motifs rather than a library of compounds. Peptide libraries based on this strategy were synthesized and screened with model targets streptavidin and anti-β-endorphin antibody. The screens resulted in observation of expected motifs providing evidence of the effectiveness of the suggested approach.

Original language	English (US)
Pages (from-to)	5426-5430
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	92
Issue number	12
State	Published - Jun 6 1995
Externally published	Yes

ASJC Scopus subject areas

General
Genetics

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Library of libraries : Approach to synthetic combinatorial library design and screening of "pharmacophore" motifs. / Sepetov, Nikolai F.; Krchňák, Viktor; Stanková, Magda; Wade, Shelly; Lam, Kit; Lebl, Michal.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, No. 12, 06.06.1995, p. 5426-5430.

Research output: Contribution to journal › Article › peer-review

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