Library-based lead compound discovery: Antioxidants by an analogous synthesis\deconvolutive assay strategy

Mark J. Kurth, Lisa A. Ahlberg Randall, Chixu Chen, Christian Melander, R. Bryan Miller, Kelly McAlister, Gary Reitz, Raphael Kang, Tetsuo Nakatsu, Carter Green

Research output: Contribution to journalArticle

93 Scopus citations

Abstract

A two-part demonstration project is reported which utilized analogous synthesis to reliably deliver a 27-analogue library which was then evaluated for antioxidative efficiency in a resin-free (ferric thiocyanate assay) deconvolutive assay.

Original languageEnglish (US)
Pages (from-to)5862-5864
Number of pages3
JournalJournal of Organic Chemistry
Volume59
Issue number20
StatePublished - 1994

ASJC Scopus subject areas

  • Organic Chemistry

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    Kurth, M. J., Ahlberg Randall, L. A., Chen, C., Melander, C., Bryan Miller, R., McAlister, K., Reitz, G., Kang, R., Nakatsu, T., & Green, C. (1994). Library-based lead compound discovery: Antioxidants by an analogous synthesis\deconvolutive assay strategy. Journal of Organic Chemistry, 59(20), 5862-5864.