Library-based lead compound discovery

Antioxidants by an analogous synthesis\deconvolutive assay strategy

Mark J. Kurth, Lisa A. Ahlberg Randall, Chixu Chen, Christian Melander, R. Bryan Miller, Kelly McAlister, Gary Reitz, Raphael Kang, Tetsuo Nakatsu, Carter Green

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

A two-part demonstration project is reported which utilized analogous synthesis to reliably deliver a 27-analogue library which was then evaluated for antioxidative efficiency in a resin-free (ferric thiocyanate assay) deconvolutive assay.

Original languageEnglish (US)
Pages (from-to)5862-5864
Number of pages3
JournalJournal of Organic Chemistry
Volume59
Issue number20
StatePublished - 1994

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Lead compounds
Assays
Antioxidants
Demonstrations
Resins
ferric thiocyanate

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Kurth, M. J., Ahlberg Randall, L. A., Chen, C., Melander, C., Bryan Miller, R., McAlister, K., ... Green, C. (1994). Library-based lead compound discovery: Antioxidants by an analogous synthesis\deconvolutive assay strategy. Journal of Organic Chemistry, 59(20), 5862-5864.

Library-based lead compound discovery : Antioxidants by an analogous synthesis\deconvolutive assay strategy. / Kurth, Mark J.; Ahlberg Randall, Lisa A.; Chen, Chixu; Melander, Christian; Bryan Miller, R.; McAlister, Kelly; Reitz, Gary; Kang, Raphael; Nakatsu, Tetsuo; Green, Carter.

In: Journal of Organic Chemistry, Vol. 59, No. 20, 1994, p. 5862-5864.

Research output: Contribution to journalArticle

Kurth, MJ, Ahlberg Randall, LA, Chen, C, Melander, C, Bryan Miller, R, McAlister, K, Reitz, G, Kang, R, Nakatsu, T & Green, C 1994, 'Library-based lead compound discovery: Antioxidants by an analogous synthesis\deconvolutive assay strategy', Journal of Organic Chemistry, vol. 59, no. 20, pp. 5862-5864.
Kurth MJ, Ahlberg Randall LA, Chen C, Melander C, Bryan Miller R, McAlister K et al. Library-based lead compound discovery: Antioxidants by an analogous synthesis\deconvolutive assay strategy. Journal of Organic Chemistry. 1994;59(20):5862-5864.
Kurth, Mark J. ; Ahlberg Randall, Lisa A. ; Chen, Chixu ; Melander, Christian ; Bryan Miller, R. ; McAlister, Kelly ; Reitz, Gary ; Kang, Raphael ; Nakatsu, Tetsuo ; Green, Carter. / Library-based lead compound discovery : Antioxidants by an analogous synthesis\deconvolutive assay strategy. In: Journal of Organic Chemistry. 1994 ; Vol. 59, No. 20. pp. 5862-5864.
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