Leveraging epidemiology and clinical studies of cancer outcomes: Recommendations and opportunities for translational research

Joanne W. Elena, Lois B. Travis, Naoko I. Simonds, Christine B. Ambrosone, Rachel Ballard-Barbash, Smita Bhatia, James R. Cerhan, Patricia Hartge, Rebecca S. Heist, Lawrence H. Kushi, Timothy L. Lash, Lindsay M. Morton, Kenan Onel, John P. Pierce, Leslie L. Robison, Julia H. Rowland, Deborah Schrag, Thomas A. Sellers, Daniela Seminara, Xiao Ou ShuNancy E. Thomas, Cornelia M. Ulrich, Andrew N. Freedman

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

As the number of cancer survivors continues to grow, research investigating the factors that affect cancer outcomes, such as disease recurrence, risk of second malignant neoplasms, and the late effects of cancer treatments, becomes ever more important. Numerous epidemiologic studies have investigated factors that affect cancer risk, but far fewer have addressed the extent to which demographic, lifestyle, genomic, clinical, and psychosocial factors influence cancer outcomes. To identify research priorities as well as resources and infrastructure needed to advance the field of cancer outcomes and survivorship research, the National Cancer Institute sponsored a workshop titled "Utilizing Data from Cancer Survivor Cohorts: Understanding the Current State of Knowledge and Developing Future Research Priorities" on November 3, 2011, in Washington, DC. This commentary highlights recent findings presented at the workshop, opportunities to leverage existing data, and recommendations for future research, data, and infrastructure needed to address high priority clinical and research questions. Multidisciplinary teams that include epidemiologists, clinicians, biostatisticians, and bioinformaticists will be essential to facilitate future cancer outcome studies focused on improving clinical care of cancer patients, identifying those at high risk of poor outcomes, and implementing effective interventions to ultimately improve the quality and duration of survival.

Original languageEnglish (US)
Pages (from-to)85-94
Number of pages10
JournalJournal of the National Cancer Institute
Volume105
Issue number2
DOIs
StatePublished - Jan 16 2013
Externally publishedYes

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Translational Medical Research
Epidemiology
Neoplasms
Research
Survivors
Outcome Assessment (Health Care)
Education
Clinical Studies
Second Primary Neoplasms
National Cancer Institute (U.S.)
Life Style
Epidemiologic Studies
Patient Care
Survival Rate
Demography
Psychology
Recurrence
Survival

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Elena, J. W., Travis, L. B., Simonds, N. I., Ambrosone, C. B., Ballard-Barbash, R., Bhatia, S., ... Freedman, A. N. (2013). Leveraging epidemiology and clinical studies of cancer outcomes: Recommendations and opportunities for translational research. Journal of the National Cancer Institute, 105(2), 85-94. https://doi.org/10.1093/jnci/djs473

Leveraging epidemiology and clinical studies of cancer outcomes : Recommendations and opportunities for translational research. / Elena, Joanne W.; Travis, Lois B.; Simonds, Naoko I.; Ambrosone, Christine B.; Ballard-Barbash, Rachel; Bhatia, Smita; Cerhan, James R.; Hartge, Patricia; Heist, Rebecca S.; Kushi, Lawrence H.; Lash, Timothy L.; Morton, Lindsay M.; Onel, Kenan; Pierce, John P.; Robison, Leslie L.; Rowland, Julia H.; Schrag, Deborah; Sellers, Thomas A.; Seminara, Daniela; Shu, Xiao Ou; Thomas, Nancy E.; Ulrich, Cornelia M.; Freedman, Andrew N.

In: Journal of the National Cancer Institute, Vol. 105, No. 2, 16.01.2013, p. 85-94.

Research output: Contribution to journalArticle

Elena, JW, Travis, LB, Simonds, NI, Ambrosone, CB, Ballard-Barbash, R, Bhatia, S, Cerhan, JR, Hartge, P, Heist, RS, Kushi, LH, Lash, TL, Morton, LM, Onel, K, Pierce, JP, Robison, LL, Rowland, JH, Schrag, D, Sellers, TA, Seminara, D, Shu, XO, Thomas, NE, Ulrich, CM & Freedman, AN 2013, 'Leveraging epidemiology and clinical studies of cancer outcomes: Recommendations and opportunities for translational research', Journal of the National Cancer Institute, vol. 105, no. 2, pp. 85-94. https://doi.org/10.1093/jnci/djs473
Elena, Joanne W. ; Travis, Lois B. ; Simonds, Naoko I. ; Ambrosone, Christine B. ; Ballard-Barbash, Rachel ; Bhatia, Smita ; Cerhan, James R. ; Hartge, Patricia ; Heist, Rebecca S. ; Kushi, Lawrence H. ; Lash, Timothy L. ; Morton, Lindsay M. ; Onel, Kenan ; Pierce, John P. ; Robison, Leslie L. ; Rowland, Julia H. ; Schrag, Deborah ; Sellers, Thomas A. ; Seminara, Daniela ; Shu, Xiao Ou ; Thomas, Nancy E. ; Ulrich, Cornelia M. ; Freedman, Andrew N. / Leveraging epidemiology and clinical studies of cancer outcomes : Recommendations and opportunities for translational research. In: Journal of the National Cancer Institute. 2013 ; Vol. 105, No. 2. pp. 85-94.
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