Leucine-rich repeat and immunoglobulin domain-containing protein-1 (Lrig1) negative regulatory action toward ErbB receptor tyrosine kinases is opposed by leucine-rich repeat and immunoglobulin domain-containing protein 3 (Lrig3)

Hanine Rafidi, Francisco Mercado, Michael Astudillo, William H D Fry, Matthew Saldana, Kermit L Carraway, Colleen A Sweeney

Research output: Contribution to journalArticle

22 Scopus citations


Background: Lrig1 is a negative regulator of oncogenic receptor tyrosine kinases. Results: Lrig3 opposes Lrig1 negative regulatory action and enhances ErbB receptor stability. Conclusion: Lrig1 and Lrig3 oppose one another. Significance: Despite structural homology, Lrig1 and Lrig3 are functionally distinct.

Original languageEnglish (US)
Pages (from-to)21593-21605
Number of pages13
JournalJournal of Biological Chemistry
Issue number30
StatePublished - Jul 26 2013


ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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