TY - JOUR
T1 - Letting the little light of mind shine
T2 - Advances and future directions in neurochemical detection
AU - Tjahjono, Nikki
AU - Jin, Yihan
AU - Hsu, Alice
AU - Roukes, Michael
AU - Tian, Lin
N1 - Funding Information:
We would like to thank our funding sources for supporting this work, including NIH5T32GM099608-10 (N.T.), NIAR01AG054649-05(Y.H.), NIH U01NS099726 (A.H. M.R.),NIHU01NS115579, U01NS120820 (L.T.).
Funding Information:
We would like to thank our funding sources for supporting this work, including NIH 5T32GM099608-10 (N.T.), NIA R01AG054649-05 (Y.H.), NIH U01NS099726 (A.H., M.R.), NIH U01NS115579 , U01NS120820 (L.T.).
Publisher Copyright:
© 2021 Elsevier B.V. and Japan Neuroscience Society
PY - 2021
Y1 - 2021
N2 - Synaptic transmission via neurochemical release is the fundamental process that integrates and relays encoded information in the brain to regulate physiological function, cognition, and emotion. To unravel the biochemical, biophysical, and computational mechanisms of signal processing, one needs to precisely measure the neurochemical release dynamics with molecular and cell-type specificity and high resolution. Here we reviewed the development of analytical, electrochemical, and fluorescence imaging approaches to detect neurotransmitter and neuromodulator release. We discussed the advantages and practicality in implementation of each technology for ease-of-use, flexibility for multimodal studies, and challenges for future optimization. We hope this review will provide a versatile guide for tool engineering and applications for recording neurochemical release.
AB - Synaptic transmission via neurochemical release is the fundamental process that integrates and relays encoded information in the brain to regulate physiological function, cognition, and emotion. To unravel the biochemical, biophysical, and computational mechanisms of signal processing, one needs to precisely measure the neurochemical release dynamics with molecular and cell-type specificity and high resolution. Here we reviewed the development of analytical, electrochemical, and fluorescence imaging approaches to detect neurotransmitter and neuromodulator release. We discussed the advantages and practicality in implementation of each technology for ease-of-use, flexibility for multimodal studies, and challenges for future optimization. We hope this review will provide a versatile guide for tool engineering and applications for recording neurochemical release.
KW - biosensors
KW - genetically encoded indicators
KW - microdialysis
KW - neurochemistry
KW - voltammetry
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U2 - 10.1016/j.neures.2021.11.012
DO - 10.1016/j.neures.2021.11.012
M3 - Review article
AN - SCOPUS:85122132657
JO - Neuroscience Research
JF - Neuroscience Research
SN - 0168-0102
ER -