Lesions of frontal cortex diminish the auditory mismatch negativity

K. Alho, David L Woods, A. Algazi, R. T. Knight, R. Näätänen

Research output: Contribution to journalArticle

243 Citations (Scopus)

Abstract

Event-related brain potentials to non-attended auditory stimuli were recorded from patients with dorsolateral prefrontal cortex (DPFCx) lesions and from age-matched control subjects as they performed a visual reaction time task. Auditory stimuli consisted of monoaural sequences of repetitive standard tones (1000 Hz) and occasional deviant tones of a higher frequency (1300 Hz). In comparison with control subjects, DPFCx patients showed enhanced P1 amplitudes (mean peak latency 50 msec), consistent with reduced frontally mediated gating of sensory input to the auditory cortex. The mismatch negativity (MMN) elicited by deviant tones was reduced in DPFCx patients over a broad latency range (130-210 msec), especially over the lesioned hemisphere and for tones delivered to the ear ipsilateral to the lesion. The results suggest that DPFCx and DPFCx-temporal projections play a critical role in involuntary orienting to physical changes in sequences of non-attended auditory stimuli.

Original languageEnglish (US)
Pages (from-to)353-362
Number of pages10
JournalElectroencephalography and Clinical Neurophysiology
Volume91
Issue number5
DOIs
StatePublished - 1994

Fingerprint

Frontal Lobe
Prefrontal Cortex
Sensory Gating
Auditory Cortex
Nucleic Acid Repetitive Sequences
Evoked Potentials
Reaction Time
Ear
Brain

Keywords

  • Attention
  • Auditory
  • Cortex
  • Event-related potentials
  • Evoked potential
  • Frontal
  • Hemisphere
  • Mismatch negativity
  • Orienting
  • Visual

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Lesions of frontal cortex diminish the auditory mismatch negativity. / Alho, K.; Woods, David L; Algazi, A.; Knight, R. T.; Näätänen, R.

In: Electroencephalography and Clinical Neurophysiology, Vol. 91, No. 5, 1994, p. 353-362.

Research output: Contribution to journalArticle

Alho, K. ; Woods, David L ; Algazi, A. ; Knight, R. T. ; Näätänen, R. / Lesions of frontal cortex diminish the auditory mismatch negativity. In: Electroencephalography and Clinical Neurophysiology. 1994 ; Vol. 91, No. 5. pp. 353-362.
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