Lesions of ascending dopaminergic pathways decrease forebrain glucose uptake

William J. Schwartz, Frank R Sharp, Rufus H. Gunn, Edward V. Evarts

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

WE describe the changes in forebrain glucose uptake following various lesions of ascending catecholaminergic pathways. These pathways include dopaminergic fibres arising from the pars compacta of the substantia nigra (A9 of Dahlström and Fuxe1) and from other cell bodies in the ventral tegmentum (A8, A10) and noradrenergic fibres originating from the locus coeruleus (A6) and from other cell bodies in the midbrain (A7) and medulla (A1, A2, A5)2. We have found that destruction of dopaminergic fibres results in decreased forebrain glucose uptake.

Original languageEnglish (US)
Pages (from-to)155-157
Number of pages3
JournalNature
Volume261
Issue number5556
DOIs
StatePublished - 1976
Externally publishedYes

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