Leptin/adiponectin ratio correlates with hepatic steatosis but not arterial stiffness in nonalcoholic fatty liver disease in Japanese population

Kenichiro Mikami, Tetsu Endo, Naoya Sawada, Go Igarashi, Masayo Kimura, Takuma Hasegawa, Chikara Iino, Hirofumi Tomita, Kaori Sawada, Shigeyuki Nakaji, Masashi Matsuzaka, Natalie J. Torok, Shinsaku Fukuda

Research output: Contribution to journalArticle

Abstract

Background and aims: Cardiovascular disease (CVD) is a leading cause of mortality in nonalcoholic fatty liver disease (NAFLD). The aim of this study was to investigate the relationship of leptin-to-adiponectin (L/A) ratio with hepatic steatosis and arterial stiffness in NAFLD. Methods: The subjects were 871 Japanese adults who participated in a health survey. Dietary intake, body composition, lipid profile, serum interleukin-6 (IL-6), leptin, and adiponectin were analyzed. NAFLD was defined as fatty liver on ultrasonography in the absence of other causes of steatosis. Arterial stiffness was evaluated by the brachial-ankle pulse wave velocity (baPWV). Results: The subjects with NAFLD had a greater body mass index (BMI) and body fat percentage (BFP); a higher intake of daily energy (kcal) and carbohydrates; and a higher prevalence of hypertension, diabetes, and hyperlipidemia. The subjects with NAFLD had higher serum leptin and lower serum adiponectin concentrations and a higher L/A ratio than subjects without NAFLD. The L/A ratio increased with increasing severity of steatosis. The L/A ratio showed positive correlations with BMI and BFP, and a negative correlation with age. Women had higher L/A ratio and BFP levels than men regardless of the presence or absence of NAFLD. There was a weak positive correlation between baPWV and severity of steatosis. BaPWV was strongly correlated with age, while no relation was found between baPWV and L/A ratio. IL-6 level was correlated with baPVW and age, while the correlation between Il and 6 level and L/A ratio was very weak. The L/A ratio was correlated with triglycerides and the ratio of total cholesterol to high-density lipoprotein-cholesterol. Conclusion: L/A ratio and arterial stiffness were associated with the severity of steatosis, whereas there was no correlation between L/A ratio and arterial stiffness in NAFLD. These findings suggest that not only leptin and adiponectin but also other factors might be involved in the pathogenesis for atherosclerosis in NAFLD.

Original languageEnglish (US)
Article number154927
JournalCytokine
Volume126
DOIs
StatePublished - Feb 2020

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Vascular Stiffness
Adiponectin
Leptin
Liver
Stiffness
Population
Pulse Wave Analysis
Ankle
Adipose Tissue
Arm
Fats
Non-alcoholic Fatty Liver Disease
Interleukin-6
Body Mass Index
Serum
Ultrasonography
Fatty Liver
Medical problems
Body Composition
Hyperlipidemias

Keywords

  • Adiponectin
  • Arterial stiffness
  • Brief-type self-administered diet history questionnaire
  • Interleukin-6
  • Leptin
  • Nonalcoholic fatty liver disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

Cite this

Leptin/adiponectin ratio correlates with hepatic steatosis but not arterial stiffness in nonalcoholic fatty liver disease in Japanese population. / Mikami, Kenichiro; Endo, Tetsu; Sawada, Naoya; Igarashi, Go; Kimura, Masayo; Hasegawa, Takuma; Iino, Chikara; Tomita, Hirofumi; Sawada, Kaori; Nakaji, Shigeyuki; Matsuzaka, Masashi; Torok, Natalie J.; Fukuda, Shinsaku.

In: Cytokine, Vol. 126, 154927, 02.2020.

Research output: Contribution to journalArticle

Mikami, K, Endo, T, Sawada, N, Igarashi, G, Kimura, M, Hasegawa, T, Iino, C, Tomita, H, Sawada, K, Nakaji, S, Matsuzaka, M, Torok, NJ & Fukuda, S 2020, 'Leptin/adiponectin ratio correlates with hepatic steatosis but not arterial stiffness in nonalcoholic fatty liver disease in Japanese population', Cytokine, vol. 126, 154927. https://doi.org/10.1016/j.cyto.2019.154927
Mikami, Kenichiro ; Endo, Tetsu ; Sawada, Naoya ; Igarashi, Go ; Kimura, Masayo ; Hasegawa, Takuma ; Iino, Chikara ; Tomita, Hirofumi ; Sawada, Kaori ; Nakaji, Shigeyuki ; Matsuzaka, Masashi ; Torok, Natalie J. ; Fukuda, Shinsaku. / Leptin/adiponectin ratio correlates with hepatic steatosis but not arterial stiffness in nonalcoholic fatty liver disease in Japanese population. In: Cytokine. 2020 ; Vol. 126.
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abstract = "Background and aims: Cardiovascular disease (CVD) is a leading cause of mortality in nonalcoholic fatty liver disease (NAFLD). The aim of this study was to investigate the relationship of leptin-to-adiponectin (L/A) ratio with hepatic steatosis and arterial stiffness in NAFLD. Methods: The subjects were 871 Japanese adults who participated in a health survey. Dietary intake, body composition, lipid profile, serum interleukin-6 (IL-6), leptin, and adiponectin were analyzed. NAFLD was defined as fatty liver on ultrasonography in the absence of other causes of steatosis. Arterial stiffness was evaluated by the brachial-ankle pulse wave velocity (baPWV). Results: The subjects with NAFLD had a greater body mass index (BMI) and body fat percentage (BFP); a higher intake of daily energy (kcal) and carbohydrates; and a higher prevalence of hypertension, diabetes, and hyperlipidemia. The subjects with NAFLD had higher serum leptin and lower serum adiponectin concentrations and a higher L/A ratio than subjects without NAFLD. The L/A ratio increased with increasing severity of steatosis. The L/A ratio showed positive correlations with BMI and BFP, and a negative correlation with age. Women had higher L/A ratio and BFP levels than men regardless of the presence or absence of NAFLD. There was a weak positive correlation between baPWV and severity of steatosis. BaPWV was strongly correlated with age, while no relation was found between baPWV and L/A ratio. IL-6 level was correlated with baPVW and age, while the correlation between Il and 6 level and L/A ratio was very weak. The L/A ratio was correlated with triglycerides and the ratio of total cholesterol to high-density lipoprotein-cholesterol. Conclusion: L/A ratio and arterial stiffness were associated with the severity of steatosis, whereas there was no correlation between L/A ratio and arterial stiffness in NAFLD. These findings suggest that not only leptin and adiponectin but also other factors might be involved in the pathogenesis for atherosclerosis in NAFLD.",
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author = "Kenichiro Mikami and Tetsu Endo and Naoya Sawada and Go Igarashi and Masayo Kimura and Takuma Hasegawa and Chikara Iino and Hirofumi Tomita and Kaori Sawada and Shigeyuki Nakaji and Masashi Matsuzaka and Torok, {Natalie J.} and Shinsaku Fukuda",
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AU - Mikami, Kenichiro

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AU - Sawada, Naoya

AU - Igarashi, Go

AU - Kimura, Masayo

AU - Hasegawa, Takuma

AU - Iino, Chikara

AU - Tomita, Hirofumi

AU - Sawada, Kaori

AU - Nakaji, Shigeyuki

AU - Matsuzaka, Masashi

AU - Torok, Natalie J.

AU - Fukuda, Shinsaku

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N2 - Background and aims: Cardiovascular disease (CVD) is a leading cause of mortality in nonalcoholic fatty liver disease (NAFLD). The aim of this study was to investigate the relationship of leptin-to-adiponectin (L/A) ratio with hepatic steatosis and arterial stiffness in NAFLD. Methods: The subjects were 871 Japanese adults who participated in a health survey. Dietary intake, body composition, lipid profile, serum interleukin-6 (IL-6), leptin, and adiponectin were analyzed. NAFLD was defined as fatty liver on ultrasonography in the absence of other causes of steatosis. Arterial stiffness was evaluated by the brachial-ankle pulse wave velocity (baPWV). Results: The subjects with NAFLD had a greater body mass index (BMI) and body fat percentage (BFP); a higher intake of daily energy (kcal) and carbohydrates; and a higher prevalence of hypertension, diabetes, and hyperlipidemia. The subjects with NAFLD had higher serum leptin and lower serum adiponectin concentrations and a higher L/A ratio than subjects without NAFLD. The L/A ratio increased with increasing severity of steatosis. The L/A ratio showed positive correlations with BMI and BFP, and a negative correlation with age. Women had higher L/A ratio and BFP levels than men regardless of the presence or absence of NAFLD. There was a weak positive correlation between baPWV and severity of steatosis. BaPWV was strongly correlated with age, while no relation was found between baPWV and L/A ratio. IL-6 level was correlated with baPVW and age, while the correlation between Il and 6 level and L/A ratio was very weak. The L/A ratio was correlated with triglycerides and the ratio of total cholesterol to high-density lipoprotein-cholesterol. Conclusion: L/A ratio and arterial stiffness were associated with the severity of steatosis, whereas there was no correlation between L/A ratio and arterial stiffness in NAFLD. These findings suggest that not only leptin and adiponectin but also other factors might be involved in the pathogenesis for atherosclerosis in NAFLD.

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KW - Interleukin-6

KW - Leptin

KW - Nonalcoholic fatty liver disease

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