Left ventricular rupture due to HIV-associated T-cell lymphoma

Ehrin J. Armstrong, Prashant Bhave, Dorothy Wong, Philip C. Ursell, Lawrence Kaplan, Yerem Yeghiazarians, Weiyun Z. Ai

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Patients with lymphoma can develop cardiac involvement that includes malignant pericardial effusions and myocardial infiltration, but extensive myocardial invasion by tumor with resultant rupture has been reported only rarely. We report a case of a patient with human immunodeficiency virus and T-cell lymphoma who presented with signs and symptoms that were suggestive of a non-ST-elevation myocardial infarction. Plans were made for cardiac catheterization, but the patient developed thrombocytopenia after the initiation of heparin and eptifibatide. Cardiac catheterization was deferred, and shortly afterwards he had a witnessed cardiac arrest in the hospital and could not be resuscitated. Autopsy revealed transmural infiltration of the myocardium with lymphoma and resultant rupture of the left ventricular free wall. To our knowledge, this is the 1st reported case of left ventricular free-wall rupture due to transmural infiltration by human-immunodeficiency-virus associated peripheral T-cell lymphoma. We conclude that noncoronary causes of chest pain, including direct myocardial infiltration, should be considered in immunocompromised patients with lymphoma.

Original languageEnglish (US)
Pages (from-to)457-460
Number of pages4
JournalTexas Heart Institute Journal
Volume37
Issue number4
StatePublished - 2010
Externally publishedYes

Fingerprint

T-Cell Lymphoma
Heart Rupture
Rupture
Lymphoma
HIV
Cardiac Catheterization
Peripheral T-Cell Lymphoma
Pericardial Effusion
Immunocompromised Host
Heart Arrest
Chest Pain
Thrombocytopenia
Signs and Symptoms
Heparin
Autopsy
Myocardium
Neoplasms

Keywords

  • Acute coronary syndromes
  • AIDS-related
  • Heart neoplasms/secondary
  • Heart rupture
  • HIV infections/complications
  • Lymphatic metastasis
  • Lymphoma
  • Myocardium/pathology
  • Neoplasm invasiveness
  • Pericardium/pathology
  • T-cell/pathology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Armstrong, E. J., Bhave, P., Wong, D., Ursell, P. C., Kaplan, L., Yeghiazarians, Y., & Ai, W. Z. (2010). Left ventricular rupture due to HIV-associated T-cell lymphoma. Texas Heart Institute Journal, 37(4), 457-460.

Left ventricular rupture due to HIV-associated T-cell lymphoma. / Armstrong, Ehrin J.; Bhave, Prashant; Wong, Dorothy; Ursell, Philip C.; Kaplan, Lawrence; Yeghiazarians, Yerem; Ai, Weiyun Z.

In: Texas Heart Institute Journal, Vol. 37, No. 4, 2010, p. 457-460.

Research output: Contribution to journalArticle

Armstrong, EJ, Bhave, P, Wong, D, Ursell, PC, Kaplan, L, Yeghiazarians, Y & Ai, WZ 2010, 'Left ventricular rupture due to HIV-associated T-cell lymphoma', Texas Heart Institute Journal, vol. 37, no. 4, pp. 457-460.
Armstrong EJ, Bhave P, Wong D, Ursell PC, Kaplan L, Yeghiazarians Y et al. Left ventricular rupture due to HIV-associated T-cell lymphoma. Texas Heart Institute Journal. 2010;37(4):457-460.
Armstrong, Ehrin J. ; Bhave, Prashant ; Wong, Dorothy ; Ursell, Philip C. ; Kaplan, Lawrence ; Yeghiazarians, Yerem ; Ai, Weiyun Z. / Left ventricular rupture due to HIV-associated T-cell lymphoma. In: Texas Heart Institute Journal. 2010 ; Vol. 37, No. 4. pp. 457-460.
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