LEF-1 activates the transcription of E2F1

Fangfang Zhou, Long Zhang, Kai Gong, Guangyuan Lu, Baiyang Sheng, Aijun Wang, Nanming Zhao, Xiufang Zhang, Yandao Gong

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

LEF-1 and E2F are both transcription factors involved in cell proliferation, differentiation and apoptosis. The present study shows for the first time that LEF-1 associates with E2F1 and further β-catenin independently activates the E2F-responsive reporter gene by attenuating the interaction between E2F1 and Histone deacetylase 1 (HDAC1), which indicates that LEF-1, except for its function in Wnt signaling, may play a distinct role via activating the transcription of E2F1.

Original languageEnglish (US)
Pages (from-to)149-153
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume365
Issue number1
DOIs
StatePublished - Jan 4 2008
Externally publishedYes

Keywords

  • E2F1
  • Histone deacetylase 1 (HDAC1)
  • LEF-1
  • Reporter gene
  • Transcription factor

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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