LEF-1 activates the transcription of E2F1

Fangfang Zhou, Long Zhang, Kai Gong, Guangyuan Lu, Baiyang Sheng, Aijun Wang, Nanming Zhao, Xiufang Zhang, Yandao Gong

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

LEF-1 and E2F are both transcription factors involved in cell proliferation, differentiation and apoptosis. The present study shows for the first time that LEF-1 associates with E2F1 and further β-catenin independently activates the E2F-responsive reporter gene by attenuating the interaction between E2F1 and Histone deacetylase 1 (HDAC1), which indicates that LEF-1, except for its function in Wnt signaling, may play a distinct role via activating the transcription of E2F1.

Original languageEnglish (US)
Pages (from-to)149-153
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume365
Issue number1
DOIs
StatePublished - Jan 4 2008
Externally publishedYes

Fingerprint

E2F1 Transcription Factor
Histone Deacetylase 1
Catenins
Cell proliferation
Transcription
Reporter Genes
Cell Differentiation
Genes
Cell Proliferation
Apoptosis

Keywords

  • E2F1
  • Histone deacetylase 1 (HDAC1)
  • LEF-1
  • Reporter gene
  • Transcription factor

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

LEF-1 activates the transcription of E2F1. / Zhou, Fangfang; Zhang, Long; Gong, Kai; Lu, Guangyuan; Sheng, Baiyang; Wang, Aijun; Zhao, Nanming; Zhang, Xiufang; Gong, Yandao.

In: Biochemical and Biophysical Research Communications, Vol. 365, No. 1, 04.01.2008, p. 149-153.

Research output: Contribution to journalArticle

Zhou, F, Zhang, L, Gong, K, Lu, G, Sheng, B, Wang, A, Zhao, N, Zhang, X & Gong, Y 2008, 'LEF-1 activates the transcription of E2F1', Biochemical and Biophysical Research Communications, vol. 365, no. 1, pp. 149-153. https://doi.org/10.1016/j.bbrc.2007.10.138
Zhou, Fangfang ; Zhang, Long ; Gong, Kai ; Lu, Guangyuan ; Sheng, Baiyang ; Wang, Aijun ; Zhao, Nanming ; Zhang, Xiufang ; Gong, Yandao. / LEF-1 activates the transcription of E2F1. In: Biochemical and Biophysical Research Communications. 2008 ; Vol. 365, No. 1. pp. 149-153.
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AU - Zhao, Nanming

AU - Zhang, Xiufang

AU - Gong, Yandao

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AB - LEF-1 and E2F are both transcription factors involved in cell proliferation, differentiation and apoptosis. The present study shows for the first time that LEF-1 associates with E2F1 and further β-catenin independently activates the E2F-responsive reporter gene by attenuating the interaction between E2F1 and Histone deacetylase 1 (HDAC1), which indicates that LEF-1, except for its function in Wnt signaling, may play a distinct role via activating the transcription of E2F1.

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