Lectin-like oxidized low-density lipoprotein receptor (LOX-1) in sickle cell disease vasculopathy

Mingyi Chen, Hong Qiu, Xin Lin, David Nam, Lucy Ogbu-Nwobodo, Hannah Archibald, Amelia Joslin, Theodore Wun, Tatsuya Sawamura, Ralph Green

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) is an endothelial receptor for oxidized LDL. Increased expression of LOX-1 has been demonstrated in atherosclerotic lesions and diabetic vasculopathy. In this study, we investigate the expression of LOX-1 receptor in sickle cell disease (SCD) vasculopathy. Expression of LOX-1 in brain vascular endothelium is markedly increased and LOX-1 gene expression is upregulated in cultured human brain microvascular endothelial cells by incubation with SCD erythrocytes. Also, the level of circulating soluble LOX-1 concentration is elevated in the plasma of SCD patients. Increased LOX-1 expression in endothelial cells is potentially involved in the pathogenesis of SCD vasculopathy. Soluble LOX-1 concentration in SCD may provide a novel biomarker for risk stratification of sickle cell vascular complications.

Original languageEnglish (US)
Pages (from-to)44-48
Number of pages5
JournalBlood Cells, Molecules, and Diseases
Volume60
DOIs
StatePublished - Sep 1 2016

Keywords

  • Adhesion molecule
  • Endothelium
  • Lectin-like oxidized low-density lipoprotein receptor (LOX-1)
  • Sickle cell disease
  • Vasculopathy

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine
  • Hematology
  • Cell Biology

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