Learning invariant features of tumor signatures

Quoc V. Le, Ju Han, Joe W. Gray, Paul T. Spellman, Alexander D Borowsky, Bahram Parvin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

23 Scopus citations

Abstract

We present a novel method for automated learning of features from unlabeled image patches for classification of tumor architecture. In contrast to previous manually-designed feature detectors (e.g., Gabor basis function), the proposed method utilizes inexpensive un-labeled data to construct features. The algorithm, also known as reconstruction independent subspace analysis, can be described as a two-layer network with non-linear responses, where the second layer represents subspace structures. The technique is applied to tissue sections for characterizing necrosis, apoptotic, and viable regions of Glioblastoma Multifrome (GBM) from TCGA dataset. Experimental results show that this method outperforms more complex expert-designed approaches. The fact that our approach learns features automatically from unlabeled data promises a wider application of self-learning strategies for tissue characterization.

Original languageEnglish (US)
Title of host publicationProceedings - International Symposium on Biomedical Imaging
Pages302-305
Number of pages4
DOIs
StatePublished - 2012
Event2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012 - Barcelona, Spain
Duration: May 2 2012May 5 2012

Other

Other2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012
CountrySpain
CityBarcelona
Period5/2/125/5/12

Keywords

  • apoptotic and necrotic signatures
  • subspace learning
  • tumor architecture

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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    Le, Q. V., Han, J., Gray, J. W., Spellman, P. T., Borowsky, A. D., & Parvin, B. (2012). Learning invariant features of tumor signatures. In Proceedings - International Symposium on Biomedical Imaging (pp. 302-305). [6235544] https://doi.org/10.1109/ISBI.2012.6235544