Lean mass and insulin resistance in women with polycystic ovary syndrome

Kevin B. Comerford, Rogelio U. Almario, Kyoungmi Kim, Siddika E Karakas

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Insulin resistance is common in women with polycystic ovary syndrome (PCOS). Muscle is the major tissue utilizing glucose while excess adipose tissue relates to insulin resistance. Thus, body composition is likely to be an important regulator of insulin sensitivity. Thirty-nine PCOS patients (age: 29.9 ± 1.0 years; BMI: 33.8 ± 1.2 kg/m 2) participated in a cross sectional study. Body composition was measured by dual energy x-ray absorptiometry (DEXA). Insulin resistance and secretion were assessed using oral glucose tolerance test (OGTT) and frequently sampled intravenous glucose tolerance test (FS-IVGTT). In contrast with the conventional expectations, lean mass correlated directly (P < .05) with the insulin resistance measure HOMA (r = 0.440); and inversely with the insulin sensitivity index QUICKI (r = -0.522) independent of fat mass. In 11 pairs of subjects matched for fat mass (35.6 ± 2.2 and 35.6 ± 2.4 kg) but with discordant lean mass (52.8 ± 1.8 vs 44.4 ± 1.6 kg), those with higher lean mass had a higher glucose response during OGTT (AUC Glucose; P = .034). In contrast, 17 pairs matched for lean mass (48.7 ± 1.7 and 48.9 ± 1.6 kg) but discordant for fat mass (43.3 ± 2.6 vs 30.3 ± 8.9 kg) showed no differences in insulin resistance parameters. These novel findings indicate that lean mass relates directly to insulin resistance in PCOS.

Original languageEnglish (US)
Pages (from-to)1256-1260
Number of pages5
JournalMetabolism: Clinical and Experimental
Issue number9
StatePublished - Sep 2012


  • acute
  • androgen index (FAI).
  • area
  • disposition
  • dual
  • energy x-ray absorptiometry (DEXA)
  • fat
  • free
  • frequently
  • glucose tolerance test (OGTT)
  • homeostatic
  • index (DI)
  • index (ISI )
  • index (SI)
  • insulin response to glucose (AIR )
  • insulin sensitivity check index (QUICKI)
  • lean
  • mass index (FMI)
  • mass index (LMI)
  • Matsuda
  • model assessment (HOMA)
  • oral
  • ovary syndrome (PCOS)
  • polycystic
  • quantitative
  • sampled intravenous glucose tolerance test (FS-IVGTT)
  • sensitivity
  • under the curve (AUC)

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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