Lawsonia intracellularis: Humoral immune response and fecal shedding in weanling foals following intra-rectal administration of frozen-thawed or lyophilized avirulent live vaccine

Nicola Pusterla, Ryan Jackson, Samantha M. Mapes, Jayme Noland, Robert M. Stenbom, Connie Gebhart

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The humoral immune response and fecal shedding of Lawsonia intracellularis was investigated in 20 weanling foals following intra-rectal administration of frozen-thawed or lyophilized avirulent live L. intracellularis vaccine. Foals received either 30 mL frozen-thawed or lyophilized vaccine intra-rectally, given twice, 4 weeks apart. Serum samples from each foal were collected every 4 weeks for 16 weeks following the first vaccination and tested for anti- L. intracellularis specific IgG by immunoperoxidase monolayer assay. Rectal swabs were collected every other day following the first vaccination for 4 weeks for detection of L. intracellularis by real-time PCR. Both vaccine formulations administered intra-rectally in weanling foals were safe and led to similar onset and duration of fecal shedding and measurable serum IgG response against L. intracellularis.

Original languageEnglish (US)
Pages (from-to)110-112
Number of pages3
JournalVeterinary Journal
Volume186
Issue number1
DOIs
StatePublished - Oct 2010

Keywords

  • Equine proliferative enteropathy
  • Fecal shedding
  • Foals
  • Lawsonia intracellularis
  • Serology
  • Vaccine

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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