Lathyrogen‐induced malformations in baboons: A preliminary report

A. J. Steffek, Andrew G Hendrickx

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Female baboons maintained on a timed pregnancy program were administered intramuscular, Intravenous, and oral doses of β‐aminopropionitrile (BAPN) and aminoacetonitrile (AAN) during the time of palatogenesis in this species. Resorptions, abortions, and fetuses with skeletal defects resulted. Cleft palate occurred in one set of twins following oral doses of 75 mg/kg/day AAN on days 43‐48 of pregnancy.

Original languageEnglish (US)
Pages (from-to)171-179
Number of pages9
JournalTeratology
Volume5
Issue number2
DOIs
StatePublished - 1972

ASJC Scopus subject areas

  • Embryology
  • Toxicology
  • Developmental Biology
  • Health, Toxicology and Mutagenesis

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