Lathyrogen‐induced malformations in baboons: A preliminary report

A. J. Steffek; Andrew G Hendrickx

doi:10.1002/tera.1420050207

Lathyrogen‐induced malformations in baboons: A preliminary report

A. J. Steffek, Andrew G Hendrickx

Cell Biology and Human Anatomy, and General

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Female baboons maintained on a timed pregnancy program were administered intramuscular, Intravenous, and oral doses of β‐aminopropionitrile (BAPN) and aminoacetonitrile (AAN) during the time of palatogenesis in this species. Resorptions, abortions, and fetuses with skeletal defects resulted. Cleft palate occurred in one set of twins following oral doses of 75 mg/kg/day AAN on days 43‐48 of pregnancy.

Original language	English (US)
Pages (from-to)	171-179
Number of pages	9
Journal	Teratology
Volume	5
Issue number	2
DOIs	https://doi.org/10.1002/tera.1420050207
State	Published - 1972

ASJC Scopus subject areas

Embryology
Toxicology
Developmental Biology
Health, Toxicology and Mutagenesis

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10.1002/tera.1420050207

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title = "Lathyrogen‐induced malformations in baboons: A preliminary report",

abstract = "Female baboons maintained on a timed pregnancy program were administered intramuscular, Intravenous, and oral doses of β‐aminopropionitrile (BAPN) and aminoacetonitrile (AAN) during the time of palatogenesis in this species. Resorptions, abortions, and fetuses with skeletal defects resulted. Cleft palate occurred in one set of twins following oral doses of 75 mg/kg/day AAN on days 43‐48 of pregnancy.",

author = "Steffek, {A. J.} and Hendrickx, {Andrew G}",

year = "1972",

doi = "10.1002/tera.1420050207",

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AB - Female baboons maintained on a timed pregnancy program were administered intramuscular, Intravenous, and oral doses of β‐aminopropionitrile (BAPN) and aminoacetonitrile (AAN) during the time of palatogenesis in this species. Resorptions, abortions, and fetuses with skeletal defects resulted. Cleft palate occurred in one set of twins following oral doses of 75 mg/kg/day AAN on days 43‐48 of pregnancy.

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Lathyrogen‐induced malformations in baboons: A preliminary report

Abstract

ASJC Scopus subject areas

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