Late-onset autoimmunity: The paradigm of primary biliary cirrhosis - A mini-review

Samuel M. Siegel, Carlo Selmi, Lorenzo Dottorini, Magda Antelmi, Massimo Zuin, Mario Lanfredini, M. Eric Gershwin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The incidence of autoimmune diseases appears to be increasing in virtually every population. This is well illustrated by primary biliary cirrhosis, a disease characterized by an immune response to small bile ducts and an incidence increasing with age. The etiology of primary biliary cirrhosis remains enigmatic, although there is clearly an interplay of genetics and environment with a possible role for immunosenescence. The increasing usage of serologic tests for the hallmark of primary biliary cirrhosis, the antimitochondrial antibody, has dramatically changed the spectrum of disease presentation and natural history. In the past, data were predominantly based on the greater prevalence of advanced cases, whereas now most patients are detected earlier through the use of multi-phasic chemistry panels. In this review, we will place the epidemiology of primary biliary cirrhosis in the context of its clinical features and treatment as well as emphasize the future directions to further understand the immunobiology of this disease.

Original languageEnglish (US)
Pages (from-to)193-201
Number of pages9
JournalGerontology
Volume54
Issue number4
DOIs
StatePublished - Jun 2008

Fingerprint

Biliary Liver Cirrhosis
Autoimmunity
Immune System Diseases
Incidence
Serologic Tests
Bile Ducts
Natural History
Autoimmune Diseases
Epidemiology
Antibodies
Population
Therapeutics

Keywords

  • Antimitochondrial antibody
  • Autoreactivity
  • Immunosenescence
  • Tolerance

ASJC Scopus subject areas

  • Aging

Cite this

Siegel, S. M., Selmi, C., Dottorini, L., Antelmi, M., Zuin, M., Lanfredini, M., & Gershwin, M. E. (2008). Late-onset autoimmunity: The paradigm of primary biliary cirrhosis - A mini-review. Gerontology, 54(4), 193-201. https://doi.org/10.1159/000138335

Late-onset autoimmunity : The paradigm of primary biliary cirrhosis - A mini-review. / Siegel, Samuel M.; Selmi, Carlo; Dottorini, Lorenzo; Antelmi, Magda; Zuin, Massimo; Lanfredini, Mario; Gershwin, M. Eric.

In: Gerontology, Vol. 54, No. 4, 06.2008, p. 193-201.

Research output: Contribution to journalArticle

Siegel, SM, Selmi, C, Dottorini, L, Antelmi, M, Zuin, M, Lanfredini, M & Gershwin, ME 2008, 'Late-onset autoimmunity: The paradigm of primary biliary cirrhosis - A mini-review', Gerontology, vol. 54, no. 4, pp. 193-201. https://doi.org/10.1159/000138335
Siegel SM, Selmi C, Dottorini L, Antelmi M, Zuin M, Lanfredini M et al. Late-onset autoimmunity: The paradigm of primary biliary cirrhosis - A mini-review. Gerontology. 2008 Jun;54(4):193-201. https://doi.org/10.1159/000138335
Siegel, Samuel M. ; Selmi, Carlo ; Dottorini, Lorenzo ; Antelmi, Magda ; Zuin, Massimo ; Lanfredini, Mario ; Gershwin, M. Eric. / Late-onset autoimmunity : The paradigm of primary biliary cirrhosis - A mini-review. In: Gerontology. 2008 ; Vol. 54, No. 4. pp. 193-201.
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