Laser-induced micropore formation and modification of cartilage structure in osteoarthritis healing

Emil Sobol, Olga Baum, Anatoly Shekhter, Sebastian Wachsmann-Hogiu, Alexander Shnirelman, Yulia Alexandrovskaya, Ivan Sadovskyy, Valerii Vinokur

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Pores are vital for functioning of avascular tissues. Laser-induced pores play an important role in the process of cartilage regeneration. The aim of any treatment for osteoarthritis is to repair hyaline-type cartilage. The aims of this study are to answer two questions: (1) How do laser-assisted pores affect the cartilaginous cells to synthesize hyaline cartilage (HC)? and (2) How can the size distribution of pores arising in the course of laser radiation be controlled? We have shown that in cartilage, the pores arise predominately near chondrocytes, which promote nutrition of cells and signal molecular transfer that activates regeneration of cartilage. In vivo laser treatment of damaged cartilage of miniature pig joints provides cellular transformation and formation of HC. We propose a simple model of pore formation in biopolymers that paves the way for going beyond the trial-anderror approach when choosing an optimal laser treatment regime. Our findings support the approach toward laser healing of osteoarthritis.

Original languageEnglish (US)
Article number091515
JournalJournal of Biomedical Optics
Volume22
Issue number9
DOIs
StatePublished - Sep 1 2017

Fingerprint

cartilage
healing
Cartilage
Lasers
porosity
lasers
regeneration
nutrition
Biopolymers
swine
biopolymers
Laser radiation
Nutrition
cells
Repair
laser beams
Tissue

Keywords

  • cartilage regeneration
  • lasers
  • osteoarthritis
  • super-resolution microscopy
  • theory of pore formation

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Biomedical Engineering

Cite this

Laser-induced micropore formation and modification of cartilage structure in osteoarthritis healing. / Sobol, Emil; Baum, Olga; Shekhter, Anatoly; Wachsmann-Hogiu, Sebastian; Shnirelman, Alexander; Alexandrovskaya, Yulia; Sadovskyy, Ivan; Vinokur, Valerii.

In: Journal of Biomedical Optics, Vol. 22, No. 9, 091515, 01.09.2017.

Research output: Contribution to journalArticle

Sobol, E, Baum, O, Shekhter, A, Wachsmann-Hogiu, S, Shnirelman, A, Alexandrovskaya, Y, Sadovskyy, I & Vinokur, V 2017, 'Laser-induced micropore formation and modification of cartilage structure in osteoarthritis healing', Journal of Biomedical Optics, vol. 22, no. 9, 091515. https://doi.org/10.1117/1.JBO.22.9.091515
Sobol, Emil ; Baum, Olga ; Shekhter, Anatoly ; Wachsmann-Hogiu, Sebastian ; Shnirelman, Alexander ; Alexandrovskaya, Yulia ; Sadovskyy, Ivan ; Vinokur, Valerii. / Laser-induced micropore formation and modification of cartilage structure in osteoarthritis healing. In: Journal of Biomedical Optics. 2017 ; Vol. 22, No. 9.
@article{d9ad7bac84bd45778ab7b1de7cee8d92,
title = "Laser-induced micropore formation and modification of cartilage structure in osteoarthritis healing",
abstract = "Pores are vital for functioning of avascular tissues. Laser-induced pores play an important role in the process of cartilage regeneration. The aim of any treatment for osteoarthritis is to repair hyaline-type cartilage. The aims of this study are to answer two questions: (1) How do laser-assisted pores affect the cartilaginous cells to synthesize hyaline cartilage (HC)? and (2) How can the size distribution of pores arising in the course of laser radiation be controlled? We have shown that in cartilage, the pores arise predominately near chondrocytes, which promote nutrition of cells and signal molecular transfer that activates regeneration of cartilage. In vivo laser treatment of damaged cartilage of miniature pig joints provides cellular transformation and formation of HC. We propose a simple model of pore formation in biopolymers that paves the way for going beyond the trial-anderror approach when choosing an optimal laser treatment regime. Our findings support the approach toward laser healing of osteoarthritis.",
keywords = "cartilage regeneration, lasers, osteoarthritis, super-resolution microscopy, theory of pore formation",
author = "Emil Sobol and Olga Baum and Anatoly Shekhter and Sebastian Wachsmann-Hogiu and Alexander Shnirelman and Yulia Alexandrovskaya and Ivan Sadovskyy and Valerii Vinokur",
year = "2017",
month = "9",
day = "1",
doi = "10.1117/1.JBO.22.9.091515",
language = "English (US)",
volume = "22",
journal = "Journal of Biomedical Optics",
issn = "1083-3668",
publisher = "SPIE",
number = "9",

}

TY - JOUR

T1 - Laser-induced micropore formation and modification of cartilage structure in osteoarthritis healing

AU - Sobol, Emil

AU - Baum, Olga

AU - Shekhter, Anatoly

AU - Wachsmann-Hogiu, Sebastian

AU - Shnirelman, Alexander

AU - Alexandrovskaya, Yulia

AU - Sadovskyy, Ivan

AU - Vinokur, Valerii

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Pores are vital for functioning of avascular tissues. Laser-induced pores play an important role in the process of cartilage regeneration. The aim of any treatment for osteoarthritis is to repair hyaline-type cartilage. The aims of this study are to answer two questions: (1) How do laser-assisted pores affect the cartilaginous cells to synthesize hyaline cartilage (HC)? and (2) How can the size distribution of pores arising in the course of laser radiation be controlled? We have shown that in cartilage, the pores arise predominately near chondrocytes, which promote nutrition of cells and signal molecular transfer that activates regeneration of cartilage. In vivo laser treatment of damaged cartilage of miniature pig joints provides cellular transformation and formation of HC. We propose a simple model of pore formation in biopolymers that paves the way for going beyond the trial-anderror approach when choosing an optimal laser treatment regime. Our findings support the approach toward laser healing of osteoarthritis.

AB - Pores are vital for functioning of avascular tissues. Laser-induced pores play an important role in the process of cartilage regeneration. The aim of any treatment for osteoarthritis is to repair hyaline-type cartilage. The aims of this study are to answer two questions: (1) How do laser-assisted pores affect the cartilaginous cells to synthesize hyaline cartilage (HC)? and (2) How can the size distribution of pores arising in the course of laser radiation be controlled? We have shown that in cartilage, the pores arise predominately near chondrocytes, which promote nutrition of cells and signal molecular transfer that activates regeneration of cartilage. In vivo laser treatment of damaged cartilage of miniature pig joints provides cellular transformation and formation of HC. We propose a simple model of pore formation in biopolymers that paves the way for going beyond the trial-anderror approach when choosing an optimal laser treatment regime. Our findings support the approach toward laser healing of osteoarthritis.

KW - cartilage regeneration

KW - lasers

KW - osteoarthritis

KW - super-resolution microscopy

KW - theory of pore formation

UR - http://www.scopus.com/inward/record.url?scp=85022068626&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85022068626&partnerID=8YFLogxK

U2 - 10.1117/1.JBO.22.9.091515

DO - 10.1117/1.JBO.22.9.091515

M3 - Article

C2 - 28564689

AN - SCOPUS:85022068626

VL - 22

JO - Journal of Biomedical Optics

JF - Journal of Biomedical Optics

SN - 1083-3668

IS - 9

M1 - 091515

ER -