Laser-induced micropore formation and modification of cartilage structure in osteoarthritis healing

Emil Sobol, Olga Baum, Anatoly Shekhter, Sebastian Wachsmann-Hogiu, Alexander Shnirelman, Yulia Alexandrovskaya, Ivan Sadovskyy, Valerii Vinokur

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Pores are vital for functioning of avascular tissues. Laser-induced pores play an important role in the process of cartilage regeneration. The aim of any treatment for osteoarthritis is to repair hyaline-type cartilage. The aims of this study are to answer two questions: (1) How do laser-assisted pores affect the cartilaginous cells to synthesize hyaline cartilage (HC)? and (2) How can the size distribution of pores arising in the course of laser radiation be controlled? We have shown that in cartilage, the pores arise predominately near chondrocytes, which promote nutrition of cells and signal molecular transfer that activates regeneration of cartilage. In vivo laser treatment of damaged cartilage of miniature pig joints provides cellular transformation and formation of HC. We propose a simple model of pore formation in biopolymers that paves the way for going beyond the trial-anderror approach when choosing an optimal laser treatment regime. Our findings support the approach toward laser healing of osteoarthritis.

Original languageEnglish (US)
Article number091515
JournalJournal of Biomedical Optics
Issue number9
StatePublished - Sep 1 2017


  • cartilage regeneration
  • lasers
  • osteoarthritis
  • super-resolution microscopy
  • theory of pore formation

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Biomedical Engineering


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