Laser atherectomy and drug-coated balloons for the treatment of femoropopliteal in-stent restenosis: 2-Year outcomes

Damianos G. Kokkinidis, Sean Behan, Omar Jawaid, Prio Hossain, Stefanos Giannopoulos, Gagan D. Singh, John R Laird, Javier A. Valle, Stephen W. Waldo, Ehrin Armstrong

Research output: Contribution to journalArticle

Abstract

Background: Femoropopliteal (FP) artery is one of the most anatomically challenging areas for sustained stent patency. The incidence of FP in-stent restenosis (ISR) is estimated at 50% at 24 months. Prior studies have shown that lesion debulking with laser atherectomy (LA) combined with drug coated balloon (DCB) have superior outcomes compared to LA + balloon angioplasty (BA) ISR, but there have not been studies evaluating 2-year outcomes. Methods: This was a dual-center retrospective cohort study that compared patients with FP-ISR treated with LA + DCB versus LA + BA. Cox regression analysis was used to examine 2-year outcomes of target lesion revascularization (TLR) and the composite outcome of TLR or restenosis. Multivariable analysis was performed for clinical and statistically significant (in the univariate analysis) variables. Results: One hundred and seventeen consecutive patients with Tosaka II (n = 32) and III (n = 85) ISR were analyzed. Sixty-six patients were treated with LA + DCB and 51 with LA + BA. The LA + DCB group had more lesions with moderate to severe calcification (58% vs. 13%; p <.0001). The LA + DCB group was more likely to be treated with the use of embolic protection devices (64% vs. 23%, p <.001) and cutting balloons (61% vs. 6%, p <.001). Bail-out stenting rates were lower in the LA + DCB group (32% vs. 57%, p =.008). LA + DCB was superior (HR: 0.57; 95% CI: 0.34–0.9, p =.027) for the composite outcome of 2-year TLR or restenosis. The 12-month KM estimates for freedom from TLR or restenosis were 66% in the LA + DCB group versus 46% in the LA + BA group. The 24-month KM estimates were 45% in the LA + DCB group versus 24% in the LA + BA group. Conclusions: The combination of DCB + LA was associated with decreased rates of bail-out stenting and improved 2-year TLR or restenosis rates. Randomized clinical trials examining the DCB + LA combination for FP-ISR are needed.

Original languageEnglish (US)
JournalCatheterization and Cardiovascular Interventions
DOIs
StateAccepted/In press - Jan 1 2019

Keywords

  • atherectomy
  • chronic total occlusions
  • drug-coated balloon
  • femoropopliteal disease
  • in-stent restenosis
  • laser
  • paclitaxel
  • peripheral artery disease

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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    Kokkinidis, D. G., Behan, S., Jawaid, O., Hossain, P., Giannopoulos, S., Singh, G. D., Laird, J. R., Valle, J. A., Waldo, S. W., & Armstrong, E. (Accepted/In press). Laser atherectomy and drug-coated balloons for the treatment of femoropopliteal in-stent restenosis: 2-Year outcomes. Catheterization and Cardiovascular Interventions. https://doi.org/10.1002/ccd.28636