Laser-assisted formation of micropores and nanobubbles in sclera promote stable normalization of intraocular pressure

Olga Baum, Sebastian Wachsmann-Hogiu, Thomas Milner, Emil Sobol

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Pores in sclera enhance uveoscleral water outflow and can normalize intraocular pressure in glaucomatous eyes. The aims of this study are to demonstrate laser-induced formation of pores with a dendritic structure and to answer the questions: How is a pore system stable and can laser treatment provide a long-lasting pressure stabilization effect? Effect of 1.56 μm laser radiation on porcine eye sclera was studied using atomic force microscopy and super resolution structured irradiation microscopy with fluorescent markers. Results suggest that the pores with a complex spatial configuration can arise as a result of laser irradiation and that laser-generated stable gas nanobubbles coated with calcium ions allow pore stabilization in the sclera. Our results support a laser based approach for treatment of glaucoma.

Original languageEnglish (US)
Article number065601
JournalLaser Physics Letters
Volume14
Issue number6
DOIs
StatePublished - Jun 1 2017

Keywords

  • fluorescence markers
  • glaucoma
  • laser modification
  • nano-bubbles
  • pore structure
  • super resolution microscopy

ASJC Scopus subject areas

  • Instrumentation
  • Physics and Astronomy (miscellaneous)

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