Laser-assisted formation of micropores and nanobubbles in sclera promote stable normalization of intraocular pressure

Olga Baum; Sebastian Wachsmann-Hogiu; Thomas Milner; Emil Sobol

doi:10.1088/1612-202X/aa6b1a

Laser-assisted formation of micropores and nanobubbles in sclera promote stable normalization of intraocular pressure

Olga Baum, Sebastian Wachsmann-Hogiu, Thomas Milner, Emil Sobol

Pathology and Laboratory Medicine

Research output: Contribution to journal › Article

9 Scopus citations

Abstract

Pores in sclera enhance uveoscleral water outflow and can normalize intraocular pressure in glaucomatous eyes. The aims of this study are to demonstrate laser-induced formation of pores with a dendritic structure and to answer the questions: How is a pore system stable and can laser treatment provide a long-lasting pressure stabilization effect? Effect of 1.56 μm laser radiation on porcine eye sclera was studied using atomic force microscopy and super resolution structured irradiation microscopy with fluorescent markers. Results suggest that the pores with a complex spatial configuration can arise as a result of laser irradiation and that laser-generated stable gas nanobubbles coated with calcium ions allow pore stabilization in the sclera. Our results support a laser based approach for treatment of glaucoma.

Original language	English (US)
Article number	065601
Journal	Laser Physics Letters
Volume	14
Issue number	6
DOIs	https://doi.org/10.1088/1612-202X/aa6b1a
State	Published - Jun 1 2017

Keywords

fluorescence markers
glaucoma
laser modification
nano-bubbles
pore structure
super resolution microscopy

ASJC Scopus subject areas

Instrumentation
Physics and Astronomy (miscellaneous)

Access to Document

10.1088/1612-202X/aa6b1a

Fingerprint Dive into the research topics of 'Laser-assisted formation of micropores and nanobubbles in sclera promote stable normalization of intraocular pressure'. Together they form a unique fingerprint.

Cite this

Baum, O., Wachsmann-Hogiu, S., Milner, T., & Sobol, E. (2017). Laser-assisted formation of micropores and nanobubbles in sclera promote stable normalization of intraocular pressure. Laser Physics Letters, 14(6), [065601]. https://doi.org/10.1088/1612-202X/aa6b1a

@article{7b937a0de6d3444fb2a7573521c66a13,

title = "Laser-assisted formation of micropores and nanobubbles in sclera promote stable normalization of intraocular pressure",

abstract = "Pores in sclera enhance uveoscleral water outflow and can normalize intraocular pressure in glaucomatous eyes. The aims of this study are to demonstrate laser-induced formation of pores with a dendritic structure and to answer the questions: How is a pore system stable and can laser treatment provide a long-lasting pressure stabilization effect? Effect of 1.56 μm laser radiation on porcine eye sclera was studied using atomic force microscopy and super resolution structured irradiation microscopy with fluorescent markers. Results suggest that the pores with a complex spatial configuration can arise as a result of laser irradiation and that laser-generated stable gas nanobubbles coated with calcium ions allow pore stabilization in the sclera. Our results support a laser based approach for treatment of glaucoma.",

keywords = "fluorescence markers, glaucoma, laser modification, nano-bubbles, pore structure, super resolution microscopy",

author = "Olga Baum and Sebastian Wachsmann-Hogiu and Thomas Milner and Emil Sobol",

year = "2017",

month = jun,

day = "1",

doi = "10.1088/1612-202X/aa6b1a",

language = "English (US)",

volume = "14",

journal = "Laser Physics Letters",

issn = "1612-2011",

publisher = "Wiley-VCH Verlag",

number = "6",

}

TY - JOUR

T1 - Laser-assisted formation of micropores and nanobubbles in sclera promote stable normalization of intraocular pressure

AU - Baum, Olga

AU - Wachsmann-Hogiu, Sebastian

AU - Milner, Thomas

AU - Sobol, Emil

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Pores in sclera enhance uveoscleral water outflow and can normalize intraocular pressure in glaucomatous eyes. The aims of this study are to demonstrate laser-induced formation of pores with a dendritic structure and to answer the questions: How is a pore system stable and can laser treatment provide a long-lasting pressure stabilization effect? Effect of 1.56 μm laser radiation on porcine eye sclera was studied using atomic force microscopy and super resolution structured irradiation microscopy with fluorescent markers. Results suggest that the pores with a complex spatial configuration can arise as a result of laser irradiation and that laser-generated stable gas nanobubbles coated with calcium ions allow pore stabilization in the sclera. Our results support a laser based approach for treatment of glaucoma.

AB - Pores in sclera enhance uveoscleral water outflow and can normalize intraocular pressure in glaucomatous eyes. The aims of this study are to demonstrate laser-induced formation of pores with a dendritic structure and to answer the questions: How is a pore system stable and can laser treatment provide a long-lasting pressure stabilization effect? Effect of 1.56 μm laser radiation on porcine eye sclera was studied using atomic force microscopy and super resolution structured irradiation microscopy with fluorescent markers. Results suggest that the pores with a complex spatial configuration can arise as a result of laser irradiation and that laser-generated stable gas nanobubbles coated with calcium ions allow pore stabilization in the sclera. Our results support a laser based approach for treatment of glaucoma.

KW - fluorescence markers

KW - glaucoma

KW - laser modification

KW - nano-bubbles

KW - pore structure

KW - super resolution microscopy

UR - http://www.scopus.com/inward/record.url?scp=85019959273&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019959273&partnerID=8YFLogxK

U2 - 10.1088/1612-202X/aa6b1a

DO - 10.1088/1612-202X/aa6b1a

M3 - Article

AN - SCOPUS:85019959273

VL - 14

JO - Laser Physics Letters

JF - Laser Physics Letters

SN - 1612-2011

IS - 6

M1 - 065601

ER -