Laser-assisted formation of micropores and nanobubbles in sclera promote stable normalization of intraocular pressure

Olga Baum; Sebastian Wachsmann-Hogiu; Thomas Milner; Emil Sobol

doi:10.1088/1612-202X/aa6b1a

Laser-assisted formation of micropores and nanobubbles in sclera promote stable normalization of intraocular pressure

Olga Baum, Sebastian Wachsmann-Hogiu, Thomas Milner, Emil Sobol

Pathology and Laboratory Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Pores in sclera enhance uveoscleral water outflow and can normalize intraocular pressure in glaucomatous eyes. The aims of this study are to demonstrate laser-induced formation of pores with a dendritic structure and to answer the questions: How is a pore system stable and can laser treatment provide a long-lasting pressure stabilization effect? Effect of 1.56 μm laser radiation on porcine eye sclera was studied using atomic force microscopy and super resolution structured irradiation microscopy with fluorescent markers. Results suggest that the pores with a complex spatial configuration can arise as a result of laser irradiation and that laser-generated stable gas nanobubbles coated with calcium ions allow pore stabilization in the sclera. Our results support a laser based approach for treatment of glaucoma.

Original language	English (US)
Article number	065601
Journal	Laser Physics Letters
Volume	14
Issue number	6
DOIs	https://doi.org/10.1088/1612-202X/aa6b1a
State	Published - Jun 1 2017

Keywords

fluorescence markers
glaucoma
laser modification
nano-bubbles
pore structure
super resolution microscopy

ASJC Scopus subject areas

Instrumentation
Physics and Astronomy (miscellaneous)

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abstract = "Pores in sclera enhance uveoscleral water outflow and can normalize intraocular pressure in glaucomatous eyes. The aims of this study are to demonstrate laser-induced formation of pores with a dendritic structure and to answer the questions: How is a pore system stable and can laser treatment provide a long-lasting pressure stabilization effect? Effect of 1.56 μm laser radiation on porcine eye sclera was studied using atomic force microscopy and super resolution structured irradiation microscopy with fluorescent markers. Results suggest that the pores with a complex spatial configuration can arise as a result of laser irradiation and that laser-generated stable gas nanobubbles coated with calcium ions allow pore stabilization in the sclera. Our results support a laser based approach for treatment of glaucoma.",

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AU - Baum, Olga

AU - Wachsmann-Hogiu, Sebastian

AU - Milner, Thomas

AU - Sobol, Emil

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Pores in sclera enhance uveoscleral water outflow and can normalize intraocular pressure in glaucomatous eyes. The aims of this study are to demonstrate laser-induced formation of pores with a dendritic structure and to answer the questions: How is a pore system stable and can laser treatment provide a long-lasting pressure stabilization effect? Effect of 1.56 μm laser radiation on porcine eye sclera was studied using atomic force microscopy and super resolution structured irradiation microscopy with fluorescent markers. Results suggest that the pores with a complex spatial configuration can arise as a result of laser irradiation and that laser-generated stable gas nanobubbles coated with calcium ions allow pore stabilization in the sclera. Our results support a laser based approach for treatment of glaucoma.

AB - Pores in sclera enhance uveoscleral water outflow and can normalize intraocular pressure in glaucomatous eyes. The aims of this study are to demonstrate laser-induced formation of pores with a dendritic structure and to answer the questions: How is a pore system stable and can laser treatment provide a long-lasting pressure stabilization effect? Effect of 1.56 μm laser radiation on porcine eye sclera was studied using atomic force microscopy and super resolution structured irradiation microscopy with fluorescent markers. Results suggest that the pores with a complex spatial configuration can arise as a result of laser irradiation and that laser-generated stable gas nanobubbles coated with calcium ions allow pore stabilization in the sclera. Our results support a laser based approach for treatment of glaucoma.

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KW - pore structure

KW - super resolution microscopy

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Laser-assisted formation of micropores and nanobubbles in sclera promote stable normalization of intraocular pressure

Abstract

Keywords

ASJC Scopus subject areas

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