Laryngeal Transplantation

Quang C Luu; D. Gregory Farwell

doi:10.1007/s40136-014-0049-6

Laryngeal Transplantation

Quang C Luu, D. Gregory Farwell

Otolaryngology

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Loss of natural voice and the presence of a laryngostoma often stigmatizes head and neck cancer surgery patients following laryngectomy. Extensive research has been performed investigating the feasibility of laryngeal transplantation in animal models. This has thus far resulted in two long-term successful human laryngeal transplantations. The procedure is technically demanding and requires immunosuppression, but leads to considerable improvement in quality of life. Additional research into better immunosuppression and surgical techniques may make laryngeal transplantation more widespread in the future.

Original language	English (US)
Pages (from-to)	192-195
Number of pages	4
Journal	Current Otorhinolaryngology Reports
Volume	2
Issue number	3
DOIs	https://doi.org/10.1007/s40136-014-0049-6
State	Published - Sep 2014

Keywords

Immunosuppression
Laryngectomy
Larynx
Transplant

ASJC Scopus subject areas

Otorhinolaryngology
Surgery
Immunology and Allergy
Clinical Neurology

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AB - Loss of natural voice and the presence of a laryngostoma often stigmatizes head and neck cancer surgery patients following laryngectomy. Extensive research has been performed investigating the feasibility of laryngeal transplantation in animal models. This has thus far resulted in two long-term successful human laryngeal transplantations. The procedure is technically demanding and requires immunosuppression, but leads to considerable improvement in quality of life. Additional research into better immunosuppression and surgical techniques may make laryngeal transplantation more widespread in the future.

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