Large uniform-sized polymer beads for use as solid-phase supports prepared by ascension polymerization

X. X. Zhu, J. H. Zhang, M. Gauthier, J. T. Luo, F. S. Meng, F. Brisse

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Large uniform-sized polymer beads are desirable for "one-bead-one- compound" applications in the combinatorial synthesis of compound libraries. We have developed a technique for the preparation of large polymer spheres with narrow size distributions. Uniform-sized poly(styrene-co- divinylbenzene) beads with diameters in excess of 1 mm have been prepared by free radical polymerization in an ascension process through a heated column. The size of the beads can be adjusted by the diameter of the injection needle and the injection speed. The resin beads can be made porous by the incorporation of a porogen during the preparation; they reach a specific surface area in excess of 200 m2/g. The mechanical properties of the spheres and their use in organic synthesis have been studied.

Original languageEnglish (US)
Pages (from-to)79-84
Number of pages6
JournalJournal of Combinatorial Chemistry
Volume8
Issue number1
DOIs
StatePublished - Jan 2006
Externally publishedYes

Fingerprint

Polymerization
Excess
Injection
Preparation
Polymers
Synthesis
Synthetic Chemistry Techniques
Free Radicals
Injections
Free radical polymerization
Surface area
Specific surface area
Needles
Libraries
Mechanical Properties
Resins
Mechanical properties
Mm
divinylbenzene-polystyrene copolymer

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Discrete Mathematics and Combinatorics

Cite this

Large uniform-sized polymer beads for use as solid-phase supports prepared by ascension polymerization. / Zhu, X. X.; Zhang, J. H.; Gauthier, M.; Luo, J. T.; Meng, F. S.; Brisse, F.

In: Journal of Combinatorial Chemistry, Vol. 8, No. 1, 01.2006, p. 79-84.

Research output: Contribution to journalArticle

Zhu, X. X. ; Zhang, J. H. ; Gauthier, M. ; Luo, J. T. ; Meng, F. S. ; Brisse, F. / Large uniform-sized polymer beads for use as solid-phase supports prepared by ascension polymerization. In: Journal of Combinatorial Chemistry. 2006 ; Vol. 8, No. 1. pp. 79-84.
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