Large uniform-sized polymer beads for use as solid-phase supports prepared by ascension polymerization

X. X. Zhu, J. H. Zhang, M. Gauthier, J. T. Luo, F. S. Meng, F. Brisse

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Large uniform-sized polymer beads are desirable for "one-bead-one- compound" applications in the combinatorial synthesis of compound libraries. We have developed a technique for the preparation of large polymer spheres with narrow size distributions. Uniform-sized poly(styrene-co- divinylbenzene) beads with diameters in excess of 1 mm have been prepared by free radical polymerization in an ascension process through a heated column. The size of the beads can be adjusted by the diameter of the injection needle and the injection speed. The resin beads can be made porous by the incorporation of a porogen during the preparation; they reach a specific surface area in excess of 200 m2/g. The mechanical properties of the spheres and their use in organic synthesis have been studied.

Original languageEnglish (US)
Pages (from-to)79-84
Number of pages6
JournalJournal of Combinatorial Chemistry
Volume8
Issue number1
DOIs
StatePublished - Jan 2006
Externally publishedYes

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Discrete Mathematics and Combinatorics

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