Large-scale synthesis of carbohydrates for pharmaceutical development

Jianbo Zhang, Bingyuan Wu, Ziye Liu, Premzek Kowal, Xi Chen, Jun Shao, Peng George Wang

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The field of glycobiology has recently enjoyed an enormous expansion boosted by new discoveries of the critical functions that carbohydrates play in nature. Further research in this area and the entry of carbohydrates into the medical and pharmaceutical fields will undoubtedly require easy access to these molecules. Recombinant glycosidases and glycosyltransferases, as well as their mutants and fusion proteins have already been applied in gram or even larger scale carbohydrate synthesis. Most efficient synthetic systems require expensive sugar nucleotides to be regenerated in situ. Solid support-immobilized biosynthetic enzymes and genetically engineered microorganisms have been demonstrated as viable and highly effective avenues to make carbohydrates. The efficiency of such systems makes them ideal for industry and should, at long last, make production of complex carbohydrates economically feasible.

Original languageEnglish (US)
Pages (from-to)1169-1176
Number of pages8
JournalCurrent Organic Chemistry
Volume5
Issue number12
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Carbohydrates
  • Engineered bacteria
  • Enzymes
  • Large-scale synthesis

ASJC Scopus subject areas

  • Organic Chemistry

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