Large-scale sequence comparisons with sourmash [version 1; peer review: 2 approved]

N. Tessa Pierce, Luiz Irber, Taylor Reiter, Phillip Brooks, C. Titus Brown

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


The sourmash software package uses MinHash-based sketching to create “signatures”, compressed representations of DNA, RNA, and protein sequences, that can be stored, searched, explored, and taxonomically annotated. sourmash signatures can be used to estimate sequence similarity between very large data sets quickly and in low memory, and can be used to search large databases of genomes for matches to query genomes and metagenomes. sourmash is implemented in C++, Rust, and Python, and is freely available under the BSD license at

Original languageEnglish (US)
Article number1006
StatePublished - Jan 1 2019
Externally publishedYes


  • Bioinformatics
  • K-mer
  • MinHash
  • Sequence analysis
  • Sourmash

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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