Large-scale pedigree analysis leads to evidence for founder effects of hypertrophic cardiomyopathy in rhesus macaques (Macaca mulatta)

Sree Kanthaswamy, Rachel Reader, Ross Tarara, Karen Oslund, Mark Allen, Jillian Ng, Chloe Grinberg, Dallas Hyde, David G. Smith, Nicholas Lerche

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Background: Hypertrophic cardiomyopathy (HCM) is the abnormal thickening of the ventricles and an increase in cardiac mass. Methods: Pedigree analyses involving 108 rhesus macaques with pronounced HCM were performed. Results: Analyses revealed a strong genetic predisposition to this disease. Conclusions: Macaques are ideal for investigating HCM because of their marked similarity to humans genetically, physiologically, and anatomically.

Original languageEnglish (US)
Pages (from-to)288-291
Number of pages4
JournalJournal of Medical Primatology
Volume43
Issue number4
DOIs
StatePublished - 2014

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Keywords

  • Genetic disease
  • Heart disease
  • Left ventricular hypertrophy
  • Non-human primates

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Kanthaswamy, S., Reader, R., Tarara, R., Oslund, K., Allen, M., Ng, J., Grinberg, C., Hyde, D., Smith, D. G., & Lerche, N. (2014). Large-scale pedigree analysis leads to evidence for founder effects of hypertrophic cardiomyopathy in rhesus macaques (Macaca mulatta). Journal of Medical Primatology, 43(4), 288-291. https://doi.org/10.1111/jmp.12127