Large-scale evaluation of In Vitro amphotericin B, triazole, and echinocandin activity against Coccidioides species from U.S. institutions

George Richard Thompson, Bridget M. Barker, Nathan P. Wiederhold

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Large-scale testing of Coccidioides isolates has not been performed, and the frequency of clinical isolates with elevated amphotericin B or triazole MICs has not been evaluated. Coccidioides isolates (n = 581) underwent antifungal susceptibility testing. Elevated MIC values were observed for fluconazole (≥16 μg/ml, 37.3% of isolates; ≥32 μg/ml, 7.9% of isolates), itraconazole (≥2 μg/ml, 1.0% of isolates), posaconazole (≥1 μg/ml, 1.0% of isolates), and voriconazole (≥2 μg/ml, 1.2% of isolates). However, mold-active triazoles exhibited low MICs for the majority of isolates tested. Additional correlation with patient outcomes to determine the relevance of elevated MICs in Coccidioides isolates is needed.

Original languageEnglish (US)
Article numbere02634-16
JournalAntimicrobial Agents and Chemotherapy
Volume61
Issue number4
DOIs
StatePublished - Apr 1 2017

Fingerprint

Coccidioides
Echinocandins
Triazoles
Amphotericin B
Itraconazole
Fluconazole
Fungi
In Vitro Techniques

Keywords

  • Amphotericin B
  • Antifungal susceptibility testing
  • Caspofungin
  • Coccidioides
  • Coccidioidomycosis
  • Endemic mycoses
  • Fluconazole
  • Flucytosine
  • Itraconazole
  • Posaconazole
  • Voriconazole

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Large-scale evaluation of In Vitro amphotericin B, triazole, and echinocandin activity against Coccidioides species from U.S. institutions. / Thompson, George Richard; Barker, Bridget M.; Wiederhold, Nathan P.

In: Antimicrobial Agents and Chemotherapy, Vol. 61, No. 4, e02634-16, 01.04.2017.

Research output: Contribution to journalArticle

@article{429b3507a10340f58c78a193e706a795,
title = "Large-scale evaluation of In Vitro amphotericin B, triazole, and echinocandin activity against Coccidioides species from U.S. institutions",
abstract = "Large-scale testing of Coccidioides isolates has not been performed, and the frequency of clinical isolates with elevated amphotericin B or triazole MICs has not been evaluated. Coccidioides isolates (n = 581) underwent antifungal susceptibility testing. Elevated MIC values were observed for fluconazole (≥16 μg/ml, 37.3{\%} of isolates; ≥32 μg/ml, 7.9{\%} of isolates), itraconazole (≥2 μg/ml, 1.0{\%} of isolates), posaconazole (≥1 μg/ml, 1.0{\%} of isolates), and voriconazole (≥2 μg/ml, 1.2{\%} of isolates). However, mold-active triazoles exhibited low MICs for the majority of isolates tested. Additional correlation with patient outcomes to determine the relevance of elevated MICs in Coccidioides isolates is needed.",
keywords = "Amphotericin B, Antifungal susceptibility testing, Caspofungin, Coccidioides, Coccidioidomycosis, Endemic mycoses, Fluconazole, Flucytosine, Itraconazole, Posaconazole, Voriconazole",
author = "Thompson, {George Richard} and Barker, {Bridget M.} and Wiederhold, {Nathan P.}",
year = "2017",
month = "4",
day = "1",
doi = "10.1128/AAC.02634-16",
language = "English (US)",
volume = "61",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "4",

}

TY - JOUR

T1 - Large-scale evaluation of In Vitro amphotericin B, triazole, and echinocandin activity against Coccidioides species from U.S. institutions

AU - Thompson, George Richard

AU - Barker, Bridget M.

AU - Wiederhold, Nathan P.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Large-scale testing of Coccidioides isolates has not been performed, and the frequency of clinical isolates with elevated amphotericin B or triazole MICs has not been evaluated. Coccidioides isolates (n = 581) underwent antifungal susceptibility testing. Elevated MIC values were observed for fluconazole (≥16 μg/ml, 37.3% of isolates; ≥32 μg/ml, 7.9% of isolates), itraconazole (≥2 μg/ml, 1.0% of isolates), posaconazole (≥1 μg/ml, 1.0% of isolates), and voriconazole (≥2 μg/ml, 1.2% of isolates). However, mold-active triazoles exhibited low MICs for the majority of isolates tested. Additional correlation with patient outcomes to determine the relevance of elevated MICs in Coccidioides isolates is needed.

AB - Large-scale testing of Coccidioides isolates has not been performed, and the frequency of clinical isolates with elevated amphotericin B or triazole MICs has not been evaluated. Coccidioides isolates (n = 581) underwent antifungal susceptibility testing. Elevated MIC values were observed for fluconazole (≥16 μg/ml, 37.3% of isolates; ≥32 μg/ml, 7.9% of isolates), itraconazole (≥2 μg/ml, 1.0% of isolates), posaconazole (≥1 μg/ml, 1.0% of isolates), and voriconazole (≥2 μg/ml, 1.2% of isolates). However, mold-active triazoles exhibited low MICs for the majority of isolates tested. Additional correlation with patient outcomes to determine the relevance of elevated MICs in Coccidioides isolates is needed.

KW - Amphotericin B

KW - Antifungal susceptibility testing

KW - Caspofungin

KW - Coccidioides

KW - Coccidioidomycosis

KW - Endemic mycoses

KW - Fluconazole

KW - Flucytosine

KW - Itraconazole

KW - Posaconazole

KW - Voriconazole

UR - http://www.scopus.com/inward/record.url?scp=85017005517&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017005517&partnerID=8YFLogxK

U2 - 10.1128/AAC.02634-16

DO - 10.1128/AAC.02634-16

M3 - Article

C2 - 28096163

AN - SCOPUS:85017005517

VL - 61

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 4

M1 - e02634-16

ER -