Large-scale evaluation of In Vitro amphotericin B, triazole, and echinocandin activity against Coccidioides species from U.S. institutions

George Richard Thompson, Bridget M. Barker, Nathan P. Wiederhold

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Large-scale testing of Coccidioides isolates has not been performed, and the frequency of clinical isolates with elevated amphotericin B or triazole MICs has not been evaluated. Coccidioides isolates (n = 581) underwent antifungal susceptibility testing. Elevated MIC values were observed for fluconazole (≥16 μg/ml, 37.3% of isolates; ≥32 μg/ml, 7.9% of isolates), itraconazole (≥2 μg/ml, 1.0% of isolates), posaconazole (≥1 μg/ml, 1.0% of isolates), and voriconazole (≥2 μg/ml, 1.2% of isolates). However, mold-active triazoles exhibited low MICs for the majority of isolates tested. Additional correlation with patient outcomes to determine the relevance of elevated MICs in Coccidioides isolates is needed.

Original languageEnglish (US)
Article numbere02634-16
JournalAntimicrobial Agents and Chemotherapy
Volume61
Issue number4
DOIs
StatePublished - Apr 1 2017

Keywords

  • Amphotericin B
  • Antifungal susceptibility testing
  • Caspofungin
  • Coccidioides
  • Coccidioidomycosis
  • Endemic mycoses
  • Fluconazole
  • Flucytosine
  • Itraconazole
  • Posaconazole
  • Voriconazole

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Large-scale evaluation of In Vitro amphotericin B, triazole, and echinocandin activity against Coccidioides species from U.S. institutions'. Together they form a unique fingerprint.

Cite this