Large arteriolar component of oxygen delivery implies a safe margin of oxygen supply to cerebral tissue

Sava Sakadžić, Emiri T. Mandeville, Louis Gagnon, Joseph J. Musacchia, Mohammad A. Yaseen, Meryem A. Yucel, Joel Lefebvre, Frédéric Lesage, Anders M. Dale, Katharina Eikermann-Haerter, Cenk Ayata, Vivek Srinivasan, Eng H. Lo, Anna Devor, David A. Boas

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92 Scopus citations

Abstract

What is the organization of cerebral microvascular oxygenation and morphology that allows adequate tissue oxygenation at different activity levels? We address this question in the mouse cerebral cortex using microscopic imaging of intravascular O2 partial pressure and blood flow combined with numerical modelling. Here we show that parenchymal arterioles are responsible for 50% of the extracted O2 at baseline activity, and the majority of the remaining O2 exchange takes place within the first few capillary branches. Most capillaries release little O2 at baseline acting as an O2 reserve that is recruited during increased neuronal activity or decreased blood flow. Our results challenge the common perception that capillaries are the major site of O2 delivery to cerebral tissue. The understanding of oxygenation distribution along arterio-capillary paths may have profound implications for the interpretation of blood-oxygen-level dependent (BOLD) contrast in functional magnetic resonance imaging and for evaluating microvascular O2 delivery capacity to support cerebral tissue in disease.

Original languageEnglish (US)
Article number5734
JournalNature Communications
Volume5
DOIs
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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    Sakadžić, S., Mandeville, E. T., Gagnon, L., Musacchia, J. J., Yaseen, M. A., Yucel, M. A., Lefebvre, J., Lesage, F., Dale, A. M., Eikermann-Haerter, K., Ayata, C., Srinivasan, V., Lo, E. H., Devor, A., & Boas, D. A. (2014). Large arteriolar component of oxygen delivery implies a safe margin of oxygen supply to cerebral tissue. Nature Communications, 5, [5734]. https://doi.org/10.1038/ncomms6734