Lanthanum Binding to Murine Neuroblastoma Cells

E. El‐Fakahany, J. R. Lopez, E. Richelson

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The binding of lanthanum to murine neuroblas‐toma cells (clone N1E‐115) was studied by means of electron microscopy and x‐ray microanalysis. Lanthanum bound only to cellular membranes, in a nonuniform manner. This lanthanum binding was reduced by pharmacological agents that affect muscarinic receptors of these cells or the function of the receptors. These results suggest that this binding of lanthanum is to sites closely related to muscarinic receptors in the cells.

Original languageEnglish (US)
Pages (from-to)1687-1691
Number of pages5
JournalJournal of Neurochemistry
Volume40
Issue number6
DOIs
StatePublished - 1983
Externally publishedYes

Keywords

  • Calcium
  • Desensitization
  • Lanthanum
  • Mouse neuroblastoma cells
  • Muscarinic receptors

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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