Abstract
Some lanthanide-doped nanoparticles can absorb X-ray radiation and emit in the visible to near infrared spectrum via a down-conversion mechanism, making them a potentially valuable agent for in vivo imaging studies. We have studied a series of Gd3+ and Eu3+compositions in lanthanide fluorides to optimize the emission from Eu3+ upon X-ray excitation. The optimum concentration of Eu3+ that produced the most intense emission in NaGdF4 was found to be 15% molar concentration. The impact of the crystallographic phases (i.e. cubic or hexagonal) on the optical emission was investigated. Furthermore, an attempt to include a sensitizer (i.e Ce3+) in NaGdF4:Eu resulted in a reduction in the emission following X-ray excitation. A surface coating of NaGdF4:Eu nanoparticles with a gold shell showed a similar decrease in luminescence intensity by a factor of two although the gold shell offers other advantages in biomedical applications.
| Original language | English (US) |
|---|---|
| Title of host publication | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
| Volume | 8596 |
| DOIs | |
| State | Published - 2013 |
| Event | Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V - San Francisco, CA, United States Duration: Feb 4 2013 → Feb 6 2013 |
Other
| Other | Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V |
|---|---|
| Country | United States |
| City | San Francisco, CA |
| Period | 2/4/13 → 2/6/13 |
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Keywords
- europium
- gold
- imaging
- nanoparticle
- phosphor
- X-ray
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Radiology Nuclear Medicine and imaging
Cite this
Lanthanide-doped nanoparticles for hybrid X-ray/optical imaging. / Sudheendra, L.; Das, Gautom K.; Li, C.; Cherry, Simon R; Kennedy, Ian M.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8596 2013. 85960D.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Lanthanide-doped nanoparticles for hybrid X-ray/optical imaging
AU - Sudheendra, L.
AU - Das, Gautom K.
AU - Li, C.
AU - Cherry, Simon R
AU - Kennedy, Ian M.
PY - 2013
Y1 - 2013
N2 - Some lanthanide-doped nanoparticles can absorb X-ray radiation and emit in the visible to near infrared spectrum via a down-conversion mechanism, making them a potentially valuable agent for in vivo imaging studies. We have studied a series of Gd3+ and Eu3+compositions in lanthanide fluorides to optimize the emission from Eu3+ upon X-ray excitation. The optimum concentration of Eu3+ that produced the most intense emission in NaGdF4 was found to be 15% molar concentration. The impact of the crystallographic phases (i.e. cubic or hexagonal) on the optical emission was investigated. Furthermore, an attempt to include a sensitizer (i.e Ce3+) in NaGdF4:Eu resulted in a reduction in the emission following X-ray excitation. A surface coating of NaGdF4:Eu nanoparticles with a gold shell showed a similar decrease in luminescence intensity by a factor of two although the gold shell offers other advantages in biomedical applications.
AB - Some lanthanide-doped nanoparticles can absorb X-ray radiation and emit in the visible to near infrared spectrum via a down-conversion mechanism, making them a potentially valuable agent for in vivo imaging studies. We have studied a series of Gd3+ and Eu3+compositions in lanthanide fluorides to optimize the emission from Eu3+ upon X-ray excitation. The optimum concentration of Eu3+ that produced the most intense emission in NaGdF4 was found to be 15% molar concentration. The impact of the crystallographic phases (i.e. cubic or hexagonal) on the optical emission was investigated. Furthermore, an attempt to include a sensitizer (i.e Ce3+) in NaGdF4:Eu resulted in a reduction in the emission following X-ray excitation. A surface coating of NaGdF4:Eu nanoparticles with a gold shell showed a similar decrease in luminescence intensity by a factor of two although the gold shell offers other advantages in biomedical applications.
KW - europium
KW - gold
KW - imaging
KW - nanoparticle
KW - phosphor
KW - X-ray
UR - http://www.scopus.com/inward/record.url?scp=84878186008&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878186008&partnerID=8YFLogxK
U2 - 10.1117/12.2005250
DO - 10.1117/12.2005250
M3 - Conference contribution
SN - 9780819493651
VL - 8596
BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
ER -