Lanthanide-doped nanoparticles for hybrid X-ray/optical imaging

L. Sudheendra, Gautom K. Das, C. Li, Simon R Cherry, Ian M. Kennedy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Some lanthanide-doped nanoparticles can absorb X-ray radiation and emit in the visible to near infrared spectrum via a down-conversion mechanism, making them a potentially valuable agent for in vivo imaging studies. We have studied a series of Gd3+ and Eu3+compositions in lanthanide fluorides to optimize the emission from Eu3+ upon X-ray excitation. The optimum concentration of Eu3+ that produced the most intense emission in NaGdF4 was found to be 15% molar concentration. The impact of the crystallographic phases (i.e. cubic or hexagonal) on the optical emission was investigated. Furthermore, an attempt to include a sensitizer (i.e Ce3+) in NaGdF4:Eu resulted in a reduction in the emission following X-ray excitation. A surface coating of NaGdF4:Eu nanoparticles with a gold shell showed a similar decrease in luminescence intensity by a factor of two although the gold shell offers other advantages in biomedical applications.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8596
DOIs
StatePublished - 2013
EventReporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V - San Francisco, CA, United States
Duration: Feb 4 2013Feb 6 2013

Other

OtherReporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V
CountryUnited States
CitySan Francisco, CA
Period2/4/132/6/13

Fingerprint

Lanthanoid Series Elements
Optical Imaging
Rare earth elements
Nanoparticles
X-Rays
Imaging techniques
X rays
Gold
nanoparticles
gold
x rays
Fluorides
excitation
light emission
fluorides
Luminescence
infrared spectra
luminescence
Infrared radiation
coatings

Keywords

  • europium
  • gold
  • imaging
  • nanoparticle
  • phosphor
  • X-ray

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Sudheendra, L., Das, G. K., Li, C., Cherry, S. R., & Kennedy, I. M. (2013). Lanthanide-doped nanoparticles for hybrid X-ray/optical imaging. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8596). [85960D] https://doi.org/10.1117/12.2005250

Lanthanide-doped nanoparticles for hybrid X-ray/optical imaging. / Sudheendra, L.; Das, Gautom K.; Li, C.; Cherry, Simon R; Kennedy, Ian M.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8596 2013. 85960D.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sudheendra, L, Das, GK, Li, C, Cherry, SR & Kennedy, IM 2013, Lanthanide-doped nanoparticles for hybrid X-ray/optical imaging. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8596, 85960D, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V, San Francisco, CA, United States, 2/4/13. https://doi.org/10.1117/12.2005250
Sudheendra L, Das GK, Li C, Cherry SR, Kennedy IM. Lanthanide-doped nanoparticles for hybrid X-ray/optical imaging. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8596. 2013. 85960D https://doi.org/10.1117/12.2005250
Sudheendra, L. ; Das, Gautom K. ; Li, C. ; Cherry, Simon R ; Kennedy, Ian M. / Lanthanide-doped nanoparticles for hybrid X-ray/optical imaging. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8596 2013.
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