Abstract
Some lanthanide-doped nanoparticles can absorb X-ray radiation and emit in the visible to near infrared spectrum via a down-conversion mechanism, making them a potentially valuable agent for in vivo imaging studies. We have studied a series of Gd3+ and Eu3+compositions in lanthanide fluorides to optimize the emission from Eu3+ upon X-ray excitation. The optimum concentration of Eu3+ that produced the most intense emission in NaGdF4 was found to be 15% molar concentration. The impact of the crystallographic phases (i.e. cubic or hexagonal) on the optical emission was investigated. Furthermore, an attempt to include a sensitizer (i.e Ce3+) in NaGdF4:Eu resulted in a reduction in the emission following X-ray excitation. A surface coating of NaGdF4:Eu nanoparticles with a gold shell showed a similar decrease in luminescence intensity by a factor of two although the gold shell offers other advantages in biomedical applications.
Original language | English (US) |
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Title of host publication | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
Volume | 8596 |
DOIs | |
State | Published - 2013 |
Event | Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V - San Francisco, CA, United States Duration: Feb 4 2013 → Feb 6 2013 |
Other
Other | Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V |
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Country | United States |
City | San Francisco, CA |
Period | 2/4/13 → 2/6/13 |
Keywords
- europium
- gold
- imaging
- nanoparticle
- phosphor
- X-ray
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Radiology Nuclear Medicine and imaging