Lanthanide-doped nanoparticles for hybrid X-ray/optical imaging

L. Sudheendra; Gautom K. Das; C. Li; Simon R Cherry; Ian M. Kennedy

doi:10.1117/12.2005250

Lanthanide-doped nanoparticles for hybrid X-ray/optical imaging

L. Sudheendra, Gautom K. Das, C. Li, Simon R Cherry, Ian M. Kennedy

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

Some lanthanide-doped nanoparticles can absorb X-ray radiation and emit in the visible to near infrared spectrum via a down-conversion mechanism, making them a potentially valuable agent for in vivo imaging studies. We have studied a series of Gd³⁺ and Eu³⁺compositions in lanthanide fluorides to optimize the emission from Eu³⁺ upon X-ray excitation. The optimum concentration of Eu³⁺ that produced the most intense emission in NaGdF₄ was found to be 15% molar concentration. The impact of the crystallographic phases (i.e. cubic or hexagonal) on the optical emission was investigated. Furthermore, an attempt to include a sensitizer (i.e Ce³⁺) in NaGdF₄:Eu resulted in a reduction in the emission following X-ray excitation. A surface coating of NaGdF₄:Eu nanoparticles with a gold shell showed a similar decrease in luminescence intensity by a factor of two although the gold shell offers other advantages in biomedical applications.

Original language	English (US)
Title of host publication	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	8596
DOIs	https://doi.org/10.1117/12.2005250
State	Published - 2013
Event	Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V - San Francisco, CA, United States Duration: Feb 4 2013 → Feb 6 2013

Other

Other	Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V
Country/Territory	United States
City	San Francisco, CA
Period	2/4/13 → 2/6/13

Keywords

europium
gold
imaging
nanoparticle
phosphor
X-ray

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Electronic, Optical and Magnetic Materials
Biomaterials
Radiology Nuclear Medicine and imaging

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10.1117/12.2005250

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Sudheendra, L, Das, GK, Li, C, Cherry, SR & Kennedy, IM 2013, Lanthanide-doped nanoparticles for hybrid X-ray/optical imaging. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8596, 85960D, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V, San Francisco, CA, United States, 2/4/13. https://doi.org/10.1117/12.2005250

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title = "Lanthanide-doped nanoparticles for hybrid X-ray/optical imaging",

abstract = "Some lanthanide-doped nanoparticles can absorb X-ray radiation and emit in the visible to near infrared spectrum via a down-conversion mechanism, making them a potentially valuable agent for in vivo imaging studies. We have studied a series of Gd3+ and Eu3+compositions in lanthanide fluorides to optimize the emission from Eu3+ upon X-ray excitation. The optimum concentration of Eu3+ that produced the most intense emission in NaGdF4 was found to be 15% molar concentration. The impact of the crystallographic phases (i.e. cubic or hexagonal) on the optical emission was investigated. Furthermore, an attempt to include a sensitizer (i.e Ce3+) in NaGdF4:Eu resulted in a reduction in the emission following X-ray excitation. A surface coating of NaGdF4:Eu nanoparticles with a gold shell showed a similar decrease in luminescence intensity by a factor of two although the gold shell offers other advantages in biomedical applications.",

keywords = "europium, gold, imaging, nanoparticle, phosphor, X-ray",

author = "L. Sudheendra and Das, {Gautom K.} and C. Li and Cherry, {Simon R} and Kennedy, {Ian M.}",

year = "2013",

doi = "10.1117/12.2005250",

language = "English (US)",

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T1 - Lanthanide-doped nanoparticles for hybrid X-ray/optical imaging

AU - Sudheendra, L.

AU - Das, Gautom K.

AU - Li, C.

AU - Cherry, Simon R

AU - Kennedy, Ian M.

PY - 2013

Y1 - 2013

N2 - Some lanthanide-doped nanoparticles can absorb X-ray radiation and emit in the visible to near infrared spectrum via a down-conversion mechanism, making them a potentially valuable agent for in vivo imaging studies. We have studied a series of Gd3+ and Eu3+compositions in lanthanide fluorides to optimize the emission from Eu3+ upon X-ray excitation. The optimum concentration of Eu3+ that produced the most intense emission in NaGdF4 was found to be 15% molar concentration. The impact of the crystallographic phases (i.e. cubic or hexagonal) on the optical emission was investigated. Furthermore, an attempt to include a sensitizer (i.e Ce3+) in NaGdF4:Eu resulted in a reduction in the emission following X-ray excitation. A surface coating of NaGdF4:Eu nanoparticles with a gold shell showed a similar decrease in luminescence intensity by a factor of two although the gold shell offers other advantages in biomedical applications.

AB - Some lanthanide-doped nanoparticles can absorb X-ray radiation and emit in the visible to near infrared spectrum via a down-conversion mechanism, making them a potentially valuable agent for in vivo imaging studies. We have studied a series of Gd3+ and Eu3+compositions in lanthanide fluorides to optimize the emission from Eu3+ upon X-ray excitation. The optimum concentration of Eu3+ that produced the most intense emission in NaGdF4 was found to be 15% molar concentration. The impact of the crystallographic phases (i.e. cubic or hexagonal) on the optical emission was investigated. Furthermore, an attempt to include a sensitizer (i.e Ce3+) in NaGdF4:Eu resulted in a reduction in the emission following X-ray excitation. A surface coating of NaGdF4:Eu nanoparticles with a gold shell showed a similar decrease in luminescence intensity by a factor of two although the gold shell offers other advantages in biomedical applications.

KW - europium

KW - gold

KW - imaging

KW - nanoparticle

KW - phosphor

KW - X-ray

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U2 - 10.1117/12.2005250

DO - 10.1117/12.2005250

M3 - Conference contribution

AN - SCOPUS:84878186008

SN - 9780819493651

VL - 8596

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

T2 - Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V

Y2 - 4 February 2013 through 6 February 2013

ER -

Lanthanide-doped nanoparticles for hybrid X-ray/optical imaging

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Keywords

ASJC Scopus subject areas

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