Langerhans cell sarcoma: Case report and review of world literature

Theodore Zwerdling, Eric Won, Lisa Shane, Ramin Javahara, Ronald Jaffe

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Langerhans cell sarcoma is a rare malignancy with only 1 pediatric case (less than 15 y of age) reported. Here, we report the second case of Langerhans cell sarcoma in a child who presented with cord compression. This patient was treated with extensive surgical resection, postoperative chemotherapy, and involved-field radiation therapy. She completed therapy and remains in remission for 27 months. A review and analysis of all 53 cases published in the world literature is provided to help guide physicians treating this disease. Recently discovered genetic mutation involving BRAF is also discussed.

Original languageEnglish (US)
Pages (from-to)419-425
Number of pages7
JournalJournal of Pediatric Hematology/Oncology
Issue number6
StatePublished - 2014
Externally publishedYes


  • Langerhans cell sarcoma
  • pediatric
  • treatment
  • world review

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology


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