Abstract
The method of retrograde axonal transport of horseradish peroxidase (HRP) was used to identify the locations of cells of origin of the spinothalamic tract in the cat. Injections of from 0.2–3.0 μl of 30% HRP were made unilaterally in various regions of the somatosensory thalamus. Massive injections of the caudal thalamus in several cats showed the spinothalamic cells of origin to be located mainly in laminae I, VII and VIII in the lumbar enlargement, and in laminae I, V and VII–VIII in the cervical enlargement. Small injections of HRP were made into the three major spinothalamic terminal zones in the thalamus, to determine the laminar origin(s) of the spinal projections to each zone. Neurons in lamina I in both cervical and lumbar enlargements were found to project almost exclusively to the rostral VB‐caudal VL border zone. A small number of neurons in laminae VII and VIII also project there but a larger number project to the intralaminar region. Neurons projecting to the PO regions were located mainly in laminae IV and V. This anatomical segregation of thalamic afferents probably reflects a functional segregation of input, since the functional properties of spinal neurons vary according to their laminar location. Comparison of these data with the differential projection spinothalamic neurons in the rat and monkey indicate that it is unlikely that the proposed “paleo‐” and “neospinothalamic” systems would arise from anatomically separate groups of spinal neurons.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 151-165 |
| Number of pages | 15 |
| Journal | Journal of Comparative Neurology |
| Volume | 182 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1978 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
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Laminar origins of spinothalamic projections in the cat as determined by the retrograde transport of horseradish peroxidase. / Carstens, Earl; Trevino, Daniel L.
In: Journal of Comparative Neurology, Vol. 182, No. 1, 1978, p. 151-165.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Laminar origins of spinothalamic projections in the cat as determined by the retrograde transport of horseradish peroxidase
AU - Carstens, Earl
AU - Trevino, Daniel L.
PY - 1978
Y1 - 1978
N2 - The method of retrograde axonal transport of horseradish peroxidase (HRP) was used to identify the locations of cells of origin of the spinothalamic tract in the cat. Injections of from 0.2–3.0 μl of 30% HRP were made unilaterally in various regions of the somatosensory thalamus. Massive injections of the caudal thalamus in several cats showed the spinothalamic cells of origin to be located mainly in laminae I, VII and VIII in the lumbar enlargement, and in laminae I, V and VII–VIII in the cervical enlargement. Small injections of HRP were made into the three major spinothalamic terminal zones in the thalamus, to determine the laminar origin(s) of the spinal projections to each zone. Neurons in lamina I in both cervical and lumbar enlargements were found to project almost exclusively to the rostral VB‐caudal VL border zone. A small number of neurons in laminae VII and VIII also project there but a larger number project to the intralaminar region. Neurons projecting to the PO regions were located mainly in laminae IV and V. This anatomical segregation of thalamic afferents probably reflects a functional segregation of input, since the functional properties of spinal neurons vary according to their laminar location. Comparison of these data with the differential projection spinothalamic neurons in the rat and monkey indicate that it is unlikely that the proposed “paleo‐” and “neospinothalamic” systems would arise from anatomically separate groups of spinal neurons.
AB - The method of retrograde axonal transport of horseradish peroxidase (HRP) was used to identify the locations of cells of origin of the spinothalamic tract in the cat. Injections of from 0.2–3.0 μl of 30% HRP were made unilaterally in various regions of the somatosensory thalamus. Massive injections of the caudal thalamus in several cats showed the spinothalamic cells of origin to be located mainly in laminae I, VII and VIII in the lumbar enlargement, and in laminae I, V and VII–VIII in the cervical enlargement. Small injections of HRP were made into the three major spinothalamic terminal zones in the thalamus, to determine the laminar origin(s) of the spinal projections to each zone. Neurons in lamina I in both cervical and lumbar enlargements were found to project almost exclusively to the rostral VB‐caudal VL border zone. A small number of neurons in laminae VII and VIII also project there but a larger number project to the intralaminar region. Neurons projecting to the PO regions were located mainly in laminae IV and V. This anatomical segregation of thalamic afferents probably reflects a functional segregation of input, since the functional properties of spinal neurons vary according to their laminar location. Comparison of these data with the differential projection spinothalamic neurons in the rat and monkey indicate that it is unlikely that the proposed “paleo‐” and “neospinothalamic” systems would arise from anatomically separate groups of spinal neurons.
UR - http://www.scopus.com/inward/record.url?scp=84985759080&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84985759080&partnerID=8YFLogxK
U2 - 10.1002/cne.901820110
DO - 10.1002/cne.901820110
M3 - Article
C2 - 701487
AN - SCOPUS:84985759080
VL - 182
SP - 151
EP - 165
JO - Journal of Comparative Neurology
JF - Journal of Comparative Neurology
SN - 0021-9967
IS - 1
ER -