Lactoferrin: Molecular structure and biological function

B. Lonnerdal, S. Iyer

Research output: Contribution to journalArticle

578 Citations (Scopus)

Abstract

Lactoferrin is an 80-kDa, iron-binding glycoprotein present in milk and, to a lesser extent, in exocrine fluids such as bile and tears. It consists of a single-chain polypeptide with two globular lobes and is relatively resistant to proteolysis. The complete cDNAs for lactoferrin from human milk, neutrophils, and bovine milk have been reported, and recombinant proteins have been produced. Owing to its iron-binding properties, lactoferrin has been proposed to play a role in iron uptake by the intestinal mucosa and to act as a bacteriostatic agent by withholding iron from iron-requiring bacteria. Its presence in neutrophils and its release during inflammation suggest that lactoferrin is also involved in phagocytic killing and immune responses. Additionally, lactoferrin may function in ways not related to iron-binding, e.g. as a growth factor and as a bactericidal agent. This review attempts to evaluate these proposed functions and their biological significance in more detail.

Original languageEnglish (US)
Pages (from-to)93-110
Number of pages18
JournalAnnual Review of Nutrition
Volume15
StatePublished - 1995

Fingerprint

Lactoferrin
Molecular Structure
Iron
Milk
Neutrophils
Human Milk
Intestinal Mucosa
Tears
Recombinant Proteins
Bile
Proteolysis
Intercellular Signaling Peptides and Proteins
Glycoproteins
Complementary DNA
Inflammation
Bacteria
Peptides

Keywords

  • bacteriostasis
  • growth factor
  • immune function
  • iron
  • iron absorption

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Lactoferrin : Molecular structure and biological function. / Lonnerdal, B.; Iyer, S.

In: Annual Review of Nutrition, Vol. 15, 1995, p. 93-110.

Research output: Contribution to journalArticle

Lonnerdal, B & Iyer, S 1995, 'Lactoferrin: Molecular structure and biological function', Annual Review of Nutrition, vol. 15, pp. 93-110.
Lonnerdal, B. ; Iyer, S. / Lactoferrin : Molecular structure and biological function. In: Annual Review of Nutrition. 1995 ; Vol. 15. pp. 93-110.
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