Lactitol-based poly(ether polyol) hydrogels for controlled release chemical and drug delivery systems

Jung H. Han, John M. Krochta, Mark J. Kurth, You Lo Hsieh

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


The hydroxyl groups of lactitol were propoxylated to produce poly(ether polyol) (LPEP). The average pK(a) value of hydroxyl groups of the polyol was 1.63. Cross-linked hydrogels were synthesized by esterification with chlorinated poly(ethylene glycol) bis(carboxymethyl) ether (PEGBCOCl). The swelling ratio decreased with increasing cross-linking ratio (PEGBCOCl:LPEP) from 2:1 to 4:1 in the hydrogels and was sensitive to temperature change between 25 and 55 °C and concentrations of salt and glucose. The swelling ratio did not change significantly with pH in the range of 4-9. The release profiles of a model active agent, acetylsalicylic acid, from the hydrogels showed that the diffusional release rate had a half-order dependence on time, and the diffusivity decreased with increasing cross-linking ratio. This work demonstrated that LPEP-based hydrogels can be used for controlled delivery of drugs and agrochemicals and the release rates can be controlled with the cross-linking ratio of the hydrogel.

Original languageEnglish (US)
Pages (from-to)5278-5282
Number of pages5
JournalJournal of Agricultural and Food Chemistry
Issue number11
StatePublished - 2000


  • Acetylsalicylic acid (aspirin)
  • Controlled release technology
  • Diffusion
  • Environmental sensitivity
  • Hydrogel

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Food Science
  • Chemistry (miscellaneous)


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