Lactitol-based poly(ether polyol) hydrogels for controlled release chemical and drug delivery systems

Jung H. Han, John M. Krochta, Mark J. Kurth, You Lo Hsieh

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The hydroxyl groups of lactitol were propoxylated to produce poly(ether polyol) (LPEP). The average pK(a) value of hydroxyl groups of the polyol was 1.63. Cross-linked hydrogels were synthesized by esterification with chlorinated poly(ethylene glycol) bis(carboxymethyl) ether (PEGBCOCl). The swelling ratio decreased with increasing cross-linking ratio (PEGBCOCl:LPEP) from 2:1 to 4:1 in the hydrogels and was sensitive to temperature change between 25 and 55 °C and concentrations of salt and glucose. The swelling ratio did not change significantly with pH in the range of 4-9. The release profiles of a model active agent, acetylsalicylic acid, from the hydrogels showed that the diffusional release rate had a half-order dependence on time, and the diffusivity decreased with increasing cross-linking ratio. This work demonstrated that LPEP-based hydrogels can be used for controlled delivery of drugs and agrochemicals and the release rates can be controlled with the cross-linking ratio of the hydrogel.

Original languageEnglish (US)
Pages (from-to)5278-5282
Number of pages5
JournalJournal of Agricultural and Food Chemistry
Volume48
Issue number11
DOIs
StatePublished - 2000

Keywords

  • Acetylsalicylic acid (aspirin)
  • Controlled release technology
  • Diffusion
  • Environmental sensitivity
  • Hydrogel

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Food Science
  • Chemistry (miscellaneous)

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