Abstract
OBJECTIVE: The objective of the study was to examine the association between lactation and maternal subclinical cardiovascular disease. STUDY DESIGN: The Women and Infants Study of Healthy Hearts enrolled 607 mothers who delivered a singleton between 1997 and 2002. In 2007, participating mothers underwent measurements of carotid intima-media thickness, lumen diameter, adventitial diameter, and carotid-femoral pulse wave velocity. Multivariable linear and logistic regressions were used to estimate the associations between lactation and subclinical cardiovascular disease. RESULTS: Compared with mothers who breastfed for 3 or more months after every birth, mothers who never breastfed exhibited a 0.13 mm larger lumen diameter (95% confidence interval, 0.04-0.22) and a 0.12 mm larger adventitial diameter (95% confidence interval, 0.02-0.22) in models adjusting for age, parity, birth outcome, sociodemographic variables, health-related behaviors, family history, gestational weight gain, early adult body mass index, current body mass index, C-reactive protein, blood pressure, cholesterol, triglyceride, high-density lipoprotein, glucose, and insulin levels. CONCLUSION: Mothers who do not breastfeed have vascular characteristics associated with a greater risk of cardiovascular disease.
| Original language | English (US) |
|---|---|
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 207 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 1 2012 |
| Externally published | Yes |
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Keywords
- adventitial diameter
- lactation
- subclinical cardiovascular disease
ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
Lactation and maternal subclinical cardiovascular disease among premenopausal women. / McClure, Candace K.; Catov, Janet M.; Ness, Roberta B.; Schwarz, Eleanor.
In: American Journal of Obstetrics and Gynecology, Vol. 207, No. 1, 01.07.2012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lactation and maternal subclinical cardiovascular disease among premenopausal women
AU - McClure, Candace K.
AU - Catov, Janet M.
AU - Ness, Roberta B.
AU - Schwarz, Eleanor
PY - 2012/7/1
Y1 - 2012/7/1
N2 - OBJECTIVE: The objective of the study was to examine the association between lactation and maternal subclinical cardiovascular disease. STUDY DESIGN: The Women and Infants Study of Healthy Hearts enrolled 607 mothers who delivered a singleton between 1997 and 2002. In 2007, participating mothers underwent measurements of carotid intima-media thickness, lumen diameter, adventitial diameter, and carotid-femoral pulse wave velocity. Multivariable linear and logistic regressions were used to estimate the associations between lactation and subclinical cardiovascular disease. RESULTS: Compared with mothers who breastfed for 3 or more months after every birth, mothers who never breastfed exhibited a 0.13 mm larger lumen diameter (95% confidence interval, 0.04-0.22) and a 0.12 mm larger adventitial diameter (95% confidence interval, 0.02-0.22) in models adjusting for age, parity, birth outcome, sociodemographic variables, health-related behaviors, family history, gestational weight gain, early adult body mass index, current body mass index, C-reactive protein, blood pressure, cholesterol, triglyceride, high-density lipoprotein, glucose, and insulin levels. CONCLUSION: Mothers who do not breastfeed have vascular characteristics associated with a greater risk of cardiovascular disease.
AB - OBJECTIVE: The objective of the study was to examine the association between lactation and maternal subclinical cardiovascular disease. STUDY DESIGN: The Women and Infants Study of Healthy Hearts enrolled 607 mothers who delivered a singleton between 1997 and 2002. In 2007, participating mothers underwent measurements of carotid intima-media thickness, lumen diameter, adventitial diameter, and carotid-femoral pulse wave velocity. Multivariable linear and logistic regressions were used to estimate the associations between lactation and subclinical cardiovascular disease. RESULTS: Compared with mothers who breastfed for 3 or more months after every birth, mothers who never breastfed exhibited a 0.13 mm larger lumen diameter (95% confidence interval, 0.04-0.22) and a 0.12 mm larger adventitial diameter (95% confidence interval, 0.02-0.22) in models adjusting for age, parity, birth outcome, sociodemographic variables, health-related behaviors, family history, gestational weight gain, early adult body mass index, current body mass index, C-reactive protein, blood pressure, cholesterol, triglyceride, high-density lipoprotein, glucose, and insulin levels. CONCLUSION: Mothers who do not breastfeed have vascular characteristics associated with a greater risk of cardiovascular disease.
KW - adventitial diameter
KW - lactation
KW - subclinical cardiovascular disease
UR - http://www.scopus.com/inward/record.url?scp=84862649385&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862649385&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2012.04.030
DO - 10.1016/j.ajog.2012.04.030
M3 - Article
C2 - 22727348
AN - SCOPUS:84862649385
VL - 207
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 1
ER -