Lactation and maternal subclinical cardiovascular disease among premenopausal women

Candace K. McClure, Janet M. Catov, Roberta B. Ness, Eleanor Schwarz

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

OBJECTIVE: The objective of the study was to examine the association between lactation and maternal subclinical cardiovascular disease. STUDY DESIGN: The Women and Infants Study of Healthy Hearts enrolled 607 mothers who delivered a singleton between 1997 and 2002. In 2007, participating mothers underwent measurements of carotid intima-media thickness, lumen diameter, adventitial diameter, and carotid-femoral pulse wave velocity. Multivariable linear and logistic regressions were used to estimate the associations between lactation and subclinical cardiovascular disease. RESULTS: Compared with mothers who breastfed for 3 or more months after every birth, mothers who never breastfed exhibited a 0.13 mm larger lumen diameter (95% confidence interval, 0.04-0.22) and a 0.12 mm larger adventitial diameter (95% confidence interval, 0.02-0.22) in models adjusting for age, parity, birth outcome, sociodemographic variables, health-related behaviors, family history, gestational weight gain, early adult body mass index, current body mass index, C-reactive protein, blood pressure, cholesterol, triglyceride, high-density lipoprotein, glucose, and insulin levels. CONCLUSION: Mothers who do not breastfeed have vascular characteristics associated with a greater risk of cardiovascular disease.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume207
Issue number1
DOIs
StatePublished - Jul 1 2012
Externally publishedYes

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Lactation
Cardiovascular Diseases
Mothers
Adventitia
Body Mass Index
Parturition
Confidence Intervals
Carotid Intima-Media Thickness
Pulse Wave Analysis
Thigh
Parity
C-Reactive Protein
HDL Cholesterol
Weight Gain
Blood Vessels
Linear Models
Triglycerides
Logistic Models
Insulin
Blood Pressure

Keywords

  • adventitial diameter
  • lactation
  • subclinical cardiovascular disease

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Lactation and maternal subclinical cardiovascular disease among premenopausal women. / McClure, Candace K.; Catov, Janet M.; Ness, Roberta B.; Schwarz, Eleanor.

In: American Journal of Obstetrics and Gynecology, Vol. 207, No. 1, 01.07.2012.

Research output: Contribution to journalArticle

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