Lactate infusion in anxiety research

Its evolution and practice

D. V. Sheehan, D. B. Carr, Scott M Fishman, M. M. Walsh, D. Peltier-Saxe

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The unpredictability of spontaneous unexpected panic attacks has inhibited the controlled study of this phenomenon. Previous studies demonstrated that an increase in blood lactic acid occurred concomitant with symptoms of anxiety in anxiety-prone patients who underwent standard physical exercise. The question of whether these patients had an excessive sensitivity to lactate led to the development of the lactate infusion model, in which anxiety is induced in a controlled environment. The history and current application of the lactate infusion model in the study of neurochemical correlates of panic are described, and a methodology for lactate infusion procedures is outlined.

Original languageEnglish (US)
Pages (from-to)158-165
Number of pages8
JournalJournal of Clinical Psychiatry
Volume46
Issue number5
StatePublished - 1985
Externally publishedYes

Fingerprint

Lactic Acid
Anxiety
Research
Controlled Environment
Panic
Panic Disorder
History
Exercise

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Sheehan, D. V., Carr, D. B., Fishman, S. M., Walsh, M. M., & Peltier-Saxe, D. (1985). Lactate infusion in anxiety research: Its evolution and practice. Journal of Clinical Psychiatry, 46(5), 158-165.

Lactate infusion in anxiety research : Its evolution and practice. / Sheehan, D. V.; Carr, D. B.; Fishman, Scott M; Walsh, M. M.; Peltier-Saxe, D.

In: Journal of Clinical Psychiatry, Vol. 46, No. 5, 1985, p. 158-165.

Research output: Contribution to journalArticle

Sheehan, DV, Carr, DB, Fishman, SM, Walsh, MM & Peltier-Saxe, D 1985, 'Lactate infusion in anxiety research: Its evolution and practice', Journal of Clinical Psychiatry, vol. 46, no. 5, pp. 158-165.
Sheehan, D. V. ; Carr, D. B. ; Fishman, Scott M ; Walsh, M. M. ; Peltier-Saxe, D. / Lactate infusion in anxiety research : Its evolution and practice. In: Journal of Clinical Psychiatry. 1985 ; Vol. 46, No. 5. pp. 158-165.
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