Lactate infusion in anxiety research: Its evolution and practice

D. V. Sheehan, D. B. Carr, Scott M Fishman, M. M. Walsh, D. Peltier-Saxe

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The unpredictability of spontaneous unexpected panic attacks has inhibited the controlled study of this phenomenon. Previous studies demonstrated that an increase in blood lactic acid occurred concomitant with symptoms of anxiety in anxiety-prone patients who underwent standard physical exercise. The question of whether these patients had an excessive sensitivity to lactate led to the development of the lactate infusion model, in which anxiety is induced in a controlled environment. The history and current application of the lactate infusion model in the study of neurochemical correlates of panic are described, and a methodology for lactate infusion procedures is outlined.

Original languageEnglish (US)
Pages (from-to)158-165
Number of pages8
JournalJournal of Clinical Psychiatry
Issue number5
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology


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