Abstract
The unpredictability of spontaneous unexpected panic attacks has inhibited the controlled study of this phenomenon. Previous studies demonstrated that an increase in blood lactic acid occurred concomitant with symptoms of anxiety in anxiety-prone patients who underwent standard physical exercise. The question of whether these patients had an excessive sensitivity to lactate led to the development of the lactate infusion model, in which anxiety is induced in a controlled environment. The history and current application of the lactate infusion model in the study of neurochemical correlates of panic are described, and a methodology for lactate infusion procedures is outlined.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 158-165 |
| Number of pages | 8 |
| Journal | Journal of Clinical Psychiatry |
| Volume | 46 |
| Issue number | 5 |
| State | Published - 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Psychiatry and Mental health
- Clinical Psychology
Cite this
Lactate infusion in anxiety research : Its evolution and practice. / Sheehan, D. V.; Carr, D. B.; Fishman, Scott M; Walsh, M. M.; Peltier-Saxe, D.
In: Journal of Clinical Psychiatry, Vol. 46, No. 5, 1985, p. 158-165.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lactate infusion in anxiety research
T2 - Its evolution and practice
AU - Sheehan, D. V.
AU - Carr, D. B.
AU - Fishman, Scott M
AU - Walsh, M. M.
AU - Peltier-Saxe, D.
PY - 1985
Y1 - 1985
N2 - The unpredictability of spontaneous unexpected panic attacks has inhibited the controlled study of this phenomenon. Previous studies demonstrated that an increase in blood lactic acid occurred concomitant with symptoms of anxiety in anxiety-prone patients who underwent standard physical exercise. The question of whether these patients had an excessive sensitivity to lactate led to the development of the lactate infusion model, in which anxiety is induced in a controlled environment. The history and current application of the lactate infusion model in the study of neurochemical correlates of panic are described, and a methodology for lactate infusion procedures is outlined.
AB - The unpredictability of spontaneous unexpected panic attacks has inhibited the controlled study of this phenomenon. Previous studies demonstrated that an increase in blood lactic acid occurred concomitant with symptoms of anxiety in anxiety-prone patients who underwent standard physical exercise. The question of whether these patients had an excessive sensitivity to lactate led to the development of the lactate infusion model, in which anxiety is induced in a controlled environment. The history and current application of the lactate infusion model in the study of neurochemical correlates of panic are described, and a methodology for lactate infusion procedures is outlined.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021885380&partnerID=8YFLogxK
M3 - Article
C2 - 3988715
AN - SCOPUS:0021885380
VL - 46
SP - 158
EP - 165
JO - Journal of Clinical Psychiatry
JF - Journal of Clinical Psychiatry
SN - 0160-6689
IS - 5
ER -