Lactate dehydrogenase activity and isoenzyme pattern in lungs, erythrocytes, and plasma of ozone-exposed rats and monkeys

C. K. Chow, Carroll E Cross, J. J. Kaneko

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The effect of low levels of ozone exposure (8 hr daily for 7 days) on lactate dehydrogenae (LDH) activity and isoenzyme pattern was studied in the lungs, plasma, and erythrocytes of rats and monkeys. Exposure to 0.8 or 0.5 ppm ozone resulted in a significant increase in total LDH activity in the lungs but not in the plasma and erythrocytes of rats. The LDH-5 fraction of the LDH isoenzymes was significantly decreased in terms of percentage distribution in the lungs and plasma of rats exposed to 0.8 ppm ozone, whereas the LDH-4 in the lungs and plasma and LDH-3 in the lungs were increased. At 0.5 ppm ozone, the isoenzyme distribution was not significantly changed in lungs, plasma or erythrocytes. In monkeys, no significant change in either total LDH activity or isoenzyme pattern was observed in lungs, plasma, or erythrocytes after exposure to 0.8 ppm ozone.

Original languageEnglish (US)
Pages (from-to)877-884
Number of pages8
JournalJournal of Toxicology and Environmental Health
Volume3
Issue number5-6
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

  • Pollution
  • Toxicology

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