Lack of quinine-evoked activity in rat trigeminal subnucleus caudalis

Christopher T. Simons, Yves Boucher, Mirela Iodi Carstens, Earl Carstens

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Conflicting reports exist regarding the ability of quinine to activate neurons in the trigeminal system. We used the complementary approaches of single-unit electrophysiology and c-fos immunohistochemistry to investigate whether quinine (100 mM) activates chemonociceptive cells in the brainstem trigeminal subnucleus caudalis (Vc). In electrophysiological experiments, 38 units responded to noxious mechanical, thermal and chemical (200 mM pentanoic acid) stimuli applied to the tongue with an increase in firing rate; none responded to lingual quinine whether the quinine was presented before or after application of pentanoic acid. In the c-fos immunohistochemical experiment, both quinine and water elicited equivalent levels of fos-like immunoreactivity (FLI) in dorsomedial Vc that were significantly lower than the level of FLI evoked by pentanoic acid. These data collectively indicate that quinine does not elicit activity in chemonociceptive Vc neurons.

Original languageEnglish (US)
Pages (from-to)253-259
Number of pages7
JournalChemical Senses
Volume28
Issue number3
DOIs
StatePublished - Mar 2003

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Food Science
  • Neuroscience(all)
  • Physiology
  • Physiology (medical)
  • Behavioral Neuroscience

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    Simons, C. T., Boucher, Y., Carstens, M. I., & Carstens, E. (2003). Lack of quinine-evoked activity in rat trigeminal subnucleus caudalis. Chemical Senses, 28(3), 253-259. https://doi.org/10.1093/chemse/28.3.253