Lack of protection against avian cholera by vaccination with recombinant P6-like protein from pasteurella multocida

Rickie W. Kasten, Patricia S. Wakenell, Shabbir Ahmad, Tilahun Yilma, Dwight C. Hirsh

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The gene encoding the P6-like protein of Pasteurella multocida was cloned in the baculovirus expression system. Baculovirus-expressed recombinant protein was used to parenterally immunize 6-wk-old Nicholas broad-breasted white turkeys. Turkeys developed significant antibody titers to the recombinant protein as measured by enzyme-linked immunosorbent assay. Two weeks after the last immunizing injection, vaccinated turkeys were placed in contact with turkeys infected with P. multocida strain P1059, as were nonvaccinated control birds. No differences occurred in percent mortality between the two groups. We conclude that parenterally administered recombinant P6-like protein does not protect turkeys from avian cholera.

Original languageEnglish (US)
Pages (from-to)972-976
Number of pages5
JournalAvian Diseases
Volume41
Issue number4
StatePublished - Oct 1997

Keywords

  • Avian cholera
  • Pasteurella multocida
  • Vaccine

ASJC Scopus subject areas

  • Immunology
  • Cancer Research
  • veterinary(all)

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    Kasten, R. W., Wakenell, P. S., Ahmad, S., Yilma, T., & Hirsh, D. C. (1997). Lack of protection against avian cholera by vaccination with recombinant P6-like protein from pasteurella multocida. Avian Diseases, 41(4), 972-976.