Lack of evidence for an association between the frequency of mutants or translocations in circulating lymphocytes and exposure to radon gas in the home

Jane Cole, Michael H L Green, Bryn A. Bridges, Alastair P W Waugh, David M. Beare, Denis Henshaw, Rex Last, Yafei Liu, Gino A Cortopassi

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Radon measurements in the living room and main bedroom of 41 houses in the town of Street, Somerset, England have been made. Exposure levels, weighted using the formula of the UK National Radiological Protection Board, of 19- 484 Bq m-3 (about half >100 Bq m-3) were found. Blood samples were obtained from a total of 66 occupants in these homes, and the frequency of genetic alterations in lymphocytes was estimated using two different end points. Gene mutations at the hypoxanthine guanine phosphoribosyl transferase locus were determined in T lymphocytes for 65 subjects using a clonal assay, and the frequency of the BCL-2 t(14;18) translocation, a chromosomal event associated with leukemia/lymphoma, was estimated in lymphocytes using a polymerase chain reaction-based technique for 64 subjects. In neither case was a significant correlation with radon levels in the home found, in contrast to our earlier observation with a smaller series.

Original languageEnglish (US)
Pages (from-to)61-69
Number of pages9
JournalRadiation Research
Volume145
Issue number1
DOIs
StatePublished - Jan 1996

Fingerprint

radon
Radon
lymphocytes
Gases
gases
Lymphocytes
mutants
hypoxanthine
Genetic Translocation
Hypoxanthine
guanine
Guanine
Transferases
lymphoma
leukemia
transferases
towns
England
polymerase chain reaction
Lymphoma

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Biophysics
  • Radiation

Cite this

Lack of evidence for an association between the frequency of mutants or translocations in circulating lymphocytes and exposure to radon gas in the home. / Cole, Jane; Green, Michael H L; Bridges, Bryn A.; Waugh, Alastair P W; Beare, David M.; Henshaw, Denis; Last, Rex; Liu, Yafei; Cortopassi, Gino A.

In: Radiation Research, Vol. 145, No. 1, 01.1996, p. 61-69.

Research output: Contribution to journalArticle

Cole, Jane ; Green, Michael H L ; Bridges, Bryn A. ; Waugh, Alastair P W ; Beare, David M. ; Henshaw, Denis ; Last, Rex ; Liu, Yafei ; Cortopassi, Gino A. / Lack of evidence for an association between the frequency of mutants or translocations in circulating lymphocytes and exposure to radon gas in the home. In: Radiation Research. 1996 ; Vol. 145, No. 1. pp. 61-69.
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