Lack of detectable interaction between HSV-1 and integrins or tachykinins

Barbara A. Israel, Kevin T. Schultz, Christopher J Murphy

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Several viruses are known to utilize cellular integrin molecules to gain entry into cells. Because of the ability of herpes simplex virus type 1 (HSV-1) to disrupt cellular adhesion, as seen particularly in ocular infections, we examined the ability of several peptides, containing known integrin recognition sequences, to interfere with plaque formation of HSV-1 in epithelial cells. We also examined the possible involvement of tachykinins in virus entry. We did not detect any decrease in plaque formation by HSV-1 in the presence of Arg-Gly-Asp, Asp-Gly-Glu-Ala, or EILDV peptides or in the presence of monoclonal antibodies to the human β1 or β4 integrin subunit. Substance P or inhibitors of the NK1 or NK2 tachykinin receptors also had no inhibitory effects on HSV-1 plaque formation.

Original languageEnglish (US)
Pages (from-to)132-134
Number of pages3
JournalIntervirology
Volume41
Issue number2-3
StatePublished - Nov 1998
Externally publishedYes

Fingerprint

Tachykinins
Human Herpesvirus 1
Integrins
glutamyl-isoleucyl-leucyl-aspartyl-valine
aspartyl-glycyl-glutamyl-alanine
Tachykinin Receptors
Eye Infections
Virus Internalization
Substance P
Epithelial Cells
Monoclonal Antibodies
Viruses
Peptides

Keywords

  • Cellular adhesion molecules
  • Substance P
  • Viral entry
  • Viral receptors

ASJC Scopus subject areas

  • Virology

Cite this

Lack of detectable interaction between HSV-1 and integrins or tachykinins. / Israel, Barbara A.; Schultz, Kevin T.; Murphy, Christopher J.

In: Intervirology, Vol. 41, No. 2-3, 11.1998, p. 132-134.

Research output: Contribution to journalArticle

Israel, BA, Schultz, KT & Murphy, CJ 1998, 'Lack of detectable interaction between HSV-1 and integrins or tachykinins', Intervirology, vol. 41, no. 2-3, pp. 132-134.
Israel, Barbara A. ; Schultz, Kevin T. ; Murphy, Christopher J. / Lack of detectable interaction between HSV-1 and integrins or tachykinins. In: Intervirology. 1998 ; Vol. 41, No. 2-3. pp. 132-134.
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