Abstract
Objective. To determine whether elevated soluble Fas/APO-1 (sFas/APO-1) levels are associated with either autoimmune disease or evidence of flares in auto-immune disease. Methods. Thirty-seven serum samples were retrospectively obtained from normal controls and patients with laboratory evidence of autoimmune disease activity. These samples were assayed for sFas/APO-1 levels by an enzyme-linked immunosorbent assay, and hospital medical records were retrospectively reviewed for clinical and laboratory characteristics of the patients. Results. Soluble Fas/APO-1 levels did not correlate with clinical diagnoses or laboratory abnormalities. The mean and range of sFas/APO-1 levels were similar in systemic lupus erythematosus patients (including those with active disease), patients with other autoimmune diseases, and normal controls. Conclusion. These data strongly suggest that measurement of sFas/APO-1 levels is unlikely to hold clinical value or play a role in the pathogenesis of autoimmune disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1738-1743 |
| Number of pages | 6 |
| Journal | Arthritis and Rheumatism |
| Volume | 38 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1995 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
- Rheumatology
Cite this
Lack of correlation between serum soluble Fas/APO-1 levels and autoimmune disease. / Goel, Niti; Ulrich, Dawn T.; St. Clair, E. William; Fleming, Judith A.; Lynch, David H.; Seldin, Michael F.
In: Arthritis and Rheumatism, Vol. 38, No. 12, 12.1995, p. 1738-1743.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lack of correlation between serum soluble Fas/APO-1 levels and autoimmune disease
AU - Goel, Niti
AU - Ulrich, Dawn T.
AU - St. Clair, E. William
AU - Fleming, Judith A.
AU - Lynch, David H.
AU - Seldin, Michael F
PY - 1995/12
Y1 - 1995/12
N2 - Objective. To determine whether elevated soluble Fas/APO-1 (sFas/APO-1) levels are associated with either autoimmune disease or evidence of flares in auto-immune disease. Methods. Thirty-seven serum samples were retrospectively obtained from normal controls and patients with laboratory evidence of autoimmune disease activity. These samples were assayed for sFas/APO-1 levels by an enzyme-linked immunosorbent assay, and hospital medical records were retrospectively reviewed for clinical and laboratory characteristics of the patients. Results. Soluble Fas/APO-1 levels did not correlate with clinical diagnoses or laboratory abnormalities. The mean and range of sFas/APO-1 levels were similar in systemic lupus erythematosus patients (including those with active disease), patients with other autoimmune diseases, and normal controls. Conclusion. These data strongly suggest that measurement of sFas/APO-1 levels is unlikely to hold clinical value or play a role in the pathogenesis of autoimmune disease.
AB - Objective. To determine whether elevated soluble Fas/APO-1 (sFas/APO-1) levels are associated with either autoimmune disease or evidence of flares in auto-immune disease. Methods. Thirty-seven serum samples were retrospectively obtained from normal controls and patients with laboratory evidence of autoimmune disease activity. These samples were assayed for sFas/APO-1 levels by an enzyme-linked immunosorbent assay, and hospital medical records were retrospectively reviewed for clinical and laboratory characteristics of the patients. Results. Soluble Fas/APO-1 levels did not correlate with clinical diagnoses or laboratory abnormalities. The mean and range of sFas/APO-1 levels were similar in systemic lupus erythematosus patients (including those with active disease), patients with other autoimmune diseases, and normal controls. Conclusion. These data strongly suggest that measurement of sFas/APO-1 levels is unlikely to hold clinical value or play a role in the pathogenesis of autoimmune disease.
UR - http://www.scopus.com/inward/record.url?scp=0029620713&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029620713&partnerID=8YFLogxK
U2 - 10.1002/art.1780381206
DO - 10.1002/art.1780381206
M3 - Article
C2 - 8849345
AN - SCOPUS:0029620713
VL - 38
SP - 1738
EP - 1743
JO - Arthritis and Rheumatology
JF - Arthritis and Rheumatology
SN - 2326-5191
IS - 12
ER -