Lack of correlation between serum soluble Fas/APO-1 levels and autoimmune disease

Niti Goel, Dawn T. Ulrich, E. William St. Clair, Judith A. Fleming, David H. Lynch, Michael F Seldin

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


Objective. To determine whether elevated soluble Fas/APO-1 (sFas/APO-1) levels are associated with either autoimmune disease or evidence of flares in auto-immune disease. Methods. Thirty-seven serum samples were retrospectively obtained from normal controls and patients with laboratory evidence of autoimmune disease activity. These samples were assayed for sFas/APO-1 levels by an enzyme-linked immunosorbent assay, and hospital medical records were retrospectively reviewed for clinical and laboratory characteristics of the patients. Results. Soluble Fas/APO-1 levels did not correlate with clinical diagnoses or laboratory abnormalities. The mean and range of sFas/APO-1 levels were similar in systemic lupus erythematosus patients (including those with active disease), patients with other autoimmune diseases, and normal controls. Conclusion. These data strongly suggest that measurement of sFas/APO-1 levels is unlikely to hold clinical value or play a role in the pathogenesis of autoimmune disease.

Original languageEnglish (US)
Pages (from-to)1738-1743
Number of pages6
JournalArthritis and Rheumatism
Issue number12
StatePublished - Dec 1995
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Rheumatology


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