Lack of correlation between serum soluble Fas/APO-1 levels and autoimmune disease

Niti Goel, Dawn T. Ulrich, E. William St. Clair, Judith A. Fleming, David H. Lynch, Michael F Seldin

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Objective. To determine whether elevated soluble Fas/APO-1 (sFas/APO-1) levels are associated with either autoimmune disease or evidence of flares in auto-immune disease. Methods. Thirty-seven serum samples were retrospectively obtained from normal controls and patients with laboratory evidence of autoimmune disease activity. These samples were assayed for sFas/APO-1 levels by an enzyme-linked immunosorbent assay, and hospital medical records were retrospectively reviewed for clinical and laboratory characteristics of the patients. Results. Soluble Fas/APO-1 levels did not correlate with clinical diagnoses or laboratory abnormalities. The mean and range of sFas/APO-1 levels were similar in systemic lupus erythematosus patients (including those with active disease), patients with other autoimmune diseases, and normal controls. Conclusion. These data strongly suggest that measurement of sFas/APO-1 levels is unlikely to hold clinical value or play a role in the pathogenesis of autoimmune disease.

Original languageEnglish (US)
Pages (from-to)1738-1743
Number of pages6
JournalArthritis and Rheumatism
Volume38
Issue number12
DOIs
StatePublished - Dec 1995
Externally publishedYes

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Autoimmune Diseases
Serum
Hospital Records
Clinical Laboratory Techniques
Immune System Diseases
Systemic Lupus Erythematosus
Medical Records
Enzyme-Linked Immunosorbent Assay

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Lack of correlation between serum soluble Fas/APO-1 levels and autoimmune disease. / Goel, Niti; Ulrich, Dawn T.; St. Clair, E. William; Fleming, Judith A.; Lynch, David H.; Seldin, Michael F.

In: Arthritis and Rheumatism, Vol. 38, No. 12, 12.1995, p. 1738-1743.

Research output: Contribution to journalArticle

Goel, Niti ; Ulrich, Dawn T. ; St. Clair, E. William ; Fleming, Judith A. ; Lynch, David H. ; Seldin, Michael F. / Lack of correlation between serum soluble Fas/APO-1 levels and autoimmune disease. In: Arthritis and Rheumatism. 1995 ; Vol. 38, No. 12. pp. 1738-1743.
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