To further test the hypothesis that the activity of glutathione peroxidase measured in cytosolic fractions prepared from lung homogenates is a parameter that reflects the capacities of the lung's antioxidant defense systems, O2 toxicity was studied in rats under conditions where it was possible to modify deleterious effects caused by 90% O2 at atmospheric pressure for 3-4 days by administration of anti-inflammatory agents. Under conditions where rats were less susceptible to O2 toxicity there was no correlation between levels of glutathione peroxidase as measured in lung cytosolic fractions and manifestations of lung O2 toxicity.
|Original language||English (US)|
|Number of pages||14|
|Journal||Research Communications in Chemical Pathology and Pharmacology|
|State||Published - 1977|
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