Lack of correlation between glutathione peroxidase activities and susceptibility to O2 toxicity in rat lungs

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Abstract

To further test the hypothesis that the activity of glutathione peroxidase measured in cytosolic fractions prepared from lung homogenates is a parameter that reflects the capacities of the lung's antioxidant defense systems, O2 toxicity was studied in rats under conditions where it was possible to modify deleterious effects caused by 90% O2 at atmospheric pressure for 3-4 days by administration of anti-inflammatory agents. Under conditions where rats were less susceptible to O2 toxicity there was no correlation between levels of glutathione peroxidase as measured in lung cytosolic fractions and manifestations of lung O2 toxicity.

Original languageEnglish (US)
Pages (from-to)433-446
Number of pages14
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume17
Issue number3
StatePublished - 1977

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Glutathione Peroxidase
Toxicity
Rats
Lung
Lung Volume Measurements
Atmospheric Pressure
Atmospheric pressure
Anti-Inflammatory Agents
Antioxidants

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

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abstract = "To further test the hypothesis that the activity of glutathione peroxidase measured in cytosolic fractions prepared from lung homogenates is a parameter that reflects the capacities of the lung's antioxidant defense systems, O2 toxicity was studied in rats under conditions where it was possible to modify deleterious effects caused by 90{\%} O2 at atmospheric pressure for 3-4 days by administration of anti-inflammatory agents. Under conditions where rats were less susceptible to O2 toxicity there was no correlation between levels of glutathione peroxidase as measured in lung cytosolic fractions and manifestations of lung O2 toxicity.",
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year = "1977",
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journal = "Research Communications in Chemical Pathology and Pharmacology",
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AU - Last, Jerold A

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