Lack of clinically significant gross structural abnormalities in MRIs of older patients with schizophrenia and related psychoses

Laura L. Symonds, John M Olichney, Terry L. Jernigan, Jody Corey-Bloom, John F. Healy, Dilip V. Jeste

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

The authors examined the reports of MRI brain studies of 69 patients with DSM-III-R-diagnosed psychotic disorders (30 early-onset and 24 late-onset schizophrenia patients and 15 with other psychoses) and 41 normal comparison subjects. Participants' ages ranged from 45 to 87 years. A qualitative rating scheme determined type and severity of clinically detectable abnormalities, including volume loss, infarcts, lacunae, and white matter hyperintensities. In this clinically well-characterized sample, the vast majority of the MRIs were within normal limits. There were no significant differences between psychosis patients and normal comparison subjects or between early-onset and late-onset schizophrenia patients in frequency, type, or severity of gross structural abnormalities. The results indicate that late-onset schizophrenia and related disorders can exist without clinically significant gross structural abnormalities in the brain.

Original languageEnglish (US)
Pages (from-to)251-258
Number of pages8
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume9
Issue number2
StatePublished - Mar 1997
Externally publishedYes

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Lack of clinically significant gross structural abnormalities in MRIs of older patients with schizophrenia and related psychoses'. Together they form a unique fingerprint.

  • Cite this