Lack of association between apolipoprotein E allele ε4 and sporadic Alzheimer's disease

Lars Lannfelt, Lena Lilius, Maria Nastase, Matti Viitanen, Laura Fratiglioni, Gösta Eggertsen, Lars Berglund, Bo Angelin, Jürgen Linder, Bengt Winblad, Hans Basun

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Apolipoprotein E (apoE) is a protein involved in the transport of lipids and a component of Alzheimer's disease (AD) plaques. There are three common alleles of the apoE gene, designated ε2, ε3 and ε4. An association between familial and sporadic AD and the ε4 allele was recently reported. We have investigated Swedish Alzheimer patients and controls. The ε4 allele frequency in familial and sporadic cases and in controls was 47, 22 and 18%, respectively. There was no significant difference between sporadic AD and controls but in familial cases the increased ε4 allele frequency previously reported was confirmed.

Original languageEnglish (US)
Pages (from-to)175-178
Number of pages4
JournalNeuroscience Letters
Volume169
Issue number1-2
DOIs
StatePublished - Mar 14 1994
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Chromosome 19
  • Plaque
  • Tangle
  • β-Amyloid

ASJC Scopus subject areas

  • Neuroscience(all)

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    Lannfelt, L., Lilius, L., Nastase, M., Viitanen, M., Fratiglioni, L., Eggertsen, G., Berglund, L., Angelin, B., Linder, J., Winblad, B., & Basun, H. (1994). Lack of association between apolipoprotein E allele ε4 and sporadic Alzheimer's disease. Neuroscience Letters, 169(1-2), 175-178. https://doi.org/10.1016/0304-3940(94)90384-0