Laboratory rhesus macaque social housing and social changes: Implications for research

Darcy Hannibal, Eliza Bliss-Moreau, Jessica Vandeleest, Brenda Mccowan, John Capitanio

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Macaque species, specifically rhesus (Macaca mulatta), are the most common nonhuman primates (NHPs) used in biomedical research due to their suitability as a model of high priority diseases (e.g., HIV, obesity, cognitive aging), cost effective breeding and housing compared to most other NHPs, and close evolutionary relationship to humans. With this close evolutionary relationship, however, is a shared adaptation for a socially stimulating environment, without which both their welfare and suitability as a research model are compromised. While outdoor social group housing provides the best approximation of a social environment that matches the macaque behavioral biology in the wild, this is not always possible at all facilities, where animals may be housed indoors in small groups, in pairs, or alone. Further, animals may experience many housing changes in their lifetime depending on project needs, changes in social status, management needs, or health concerns. Here, we review the evidence for the physiological and health effects of social housing changes and the potential impacts on research outcomes for studies using macaques, particularly rhesus. We situate our review in the context of increasing regulatory pressure for research facilities to both house NHPs socially and mitigate trauma from social aggression. To meet these regulatory requirements and further refine the macaque model for research, significant advances must be made in our understanding and management of rhesus macaque social housing, particularly pair-housing since it is the most common social housing configuration for macaques while on research projects. Because most NHPs are adapted for sociality, a social context is likely important for improving repeatability, reproducibility, and external validity of primate biomedical research. Am. J. Primatol. 79:e22528, 2017.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalAmerican Journal of Primatology
Volume79
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

public housing
social change
social housing
Macaca mulatta
Primates
primate
Macaca
biomedical research
pair housing
group housing
research facilities
social environment
research projects
social status
obesity
animal
reproducibility
repeatability
human immunodeficiency virus
aggression

Keywords

  • enrichment
  • heterogeneous environment
  • pairing
  • peer interaction

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Animal Science and Zoology

Cite this

Laboratory rhesus macaque social housing and social changes : Implications for research. / Hannibal, Darcy; Bliss-Moreau, Eliza; Vandeleest, Jessica; Mccowan, Brenda; Capitanio, John.

In: American Journal of Primatology, Vol. 79, No. 1, 01.01.2017, p. 1-14.

Research output: Contribution to journalReview article

Hannibal, Darcy ; Bliss-Moreau, Eliza ; Vandeleest, Jessica ; Mccowan, Brenda ; Capitanio, John. / Laboratory rhesus macaque social housing and social changes : Implications for research. In: American Journal of Primatology. 2017 ; Vol. 79, No. 1. pp. 1-14.
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