Laboratory criteria for menopause in women using oral contraceptives

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Objective: To evaluate laboratory criteria for menopause in women taking oral contraceptives (OC). Design: Prospective, uncontrolled pilot study. Setting: San Francisco General Hospital, San Francisco, California, and Magee-Womens Hospital, Pittsburgh, Pennsylvania. Patients: Twenty-eight menopausal women. Interventions: Fourteen menopausal women received triphasic 35 μg ethinyl E2 and 180-215-250 μg norgestimate, and 14 menopausal women received monophasic 30 μg ethinyl E2150 μg desogestrel. Main Outcome Measures: Serum FSH, LH, and E2 levels were evaluated on days 14 and 28 (day 7 of the pill-free interval) of the third cycle of pills. Results: Twelve women in each group completed the study. Fifteen (62.5%) subjects still had a serum FSH <30 mIU/mL (30 IU/L) on the 7th day of the pill-free interval of the third pill package. All subjects had a serum FSH:LH ratio >1 and 20 of 21 (95%) subjects had E2 < 20 pg/mL (73 pmol/L) at the end of the pill-free interval of the third cycle. Conclusions: Measuring FSH on the 7th day of the pill-free interval is not a sensitive test for menopause. Serum FSH:LH ratio >1 or E2 < 20 pg/mL (73 pmol/L) on the 7th day of the pill-free interval may be a more appropriate marker of menopause in women using OC in the later reproductive years.

Original languageEnglish (US)
Pages (from-to)101-104
Number of pages4
JournalFertility and Sterility
Volume66
Issue number1
StatePublished - 1996
Externally publishedYes

Keywords

  • E
  • FSH
  • LH
  • menopause
  • Oral contraceptives

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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