Label-free kinetic screening of proteins and virus binding in a 51,200 small-molecule library with a high-throughput ellipsometric scanning microscope

Galina Malovichko, James P. Landry, Andrew P. Proudian, Xiangdong Zhu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Using a label-free high-throughput optical scanning microscope we detected endpoints and binding kinetics of RNPC1a, Pyl(1&2) proteins and influenza virus A/PR/8/34 with a library of 51,200 small-molecule compounds from the NCI Developmental Therapeutics Program.

Original languageEnglish (US)
Title of host publicationCLEO: Applications and Technology, CLEO_AT 2013
StatePublished - 2013
EventCLEO: Applications and Technology, CLEO_AT 2013 - San Jose, CA, United States
Duration: Jun 9 2013Jun 14 2013

Other

OtherCLEO: Applications and Technology, CLEO_AT 2013
CountryUnited States
CitySan Jose, CA
Period6/9/136/14/13

Fingerprint

influenza
viruses
Viruses
Labels
Screening
Microscopes
screening
microscopes
Throughput
proteins
Proteins
Scanning
Molecules
Kinetics
scanning
kinetics
molecules

ASJC Scopus subject areas

  • Computer Networks and Communications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Malovichko, G., Landry, J. P., Proudian, A. P., & Zhu, X. (2013). Label-free kinetic screening of proteins and virus binding in a 51,200 small-molecule library with a high-throughput ellipsometric scanning microscope. In CLEO: Applications and Technology, CLEO_AT 2013

Label-free kinetic screening of proteins and virus binding in a 51,200 small-molecule library with a high-throughput ellipsometric scanning microscope. / Malovichko, Galina; Landry, James P.; Proudian, Andrew P.; Zhu, Xiangdong.

CLEO: Applications and Technology, CLEO_AT 2013. 2013.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Malovichko, G, Landry, JP, Proudian, AP & Zhu, X 2013, Label-free kinetic screening of proteins and virus binding in a 51,200 small-molecule library with a high-throughput ellipsometric scanning microscope. in CLEO: Applications and Technology, CLEO_AT 2013. CLEO: Applications and Technology, CLEO_AT 2013, San Jose, CA, United States, 6/9/13.
Malovichko G, Landry JP, Proudian AP, Zhu X. Label-free kinetic screening of proteins and virus binding in a 51,200 small-molecule library with a high-throughput ellipsometric scanning microscope. In CLEO: Applications and Technology, CLEO_AT 2013. 2013
Malovichko, Galina ; Landry, James P. ; Proudian, Andrew P. ; Zhu, Xiangdong. / Label-free kinetic screening of proteins and virus binding in a 51,200 small-molecule library with a high-throughput ellipsometric scanning microscope. CLEO: Applications and Technology, CLEO_AT 2013. 2013.
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