Label-free detection of microarrays of biomolecules by oblique-incidence reflectivity difference microscopy

J. P. Landry, X. D. Zhu, Jeffrey Gregg

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

We developed an oblique-incidence reflectivity difference (OI-RD) scanning microscope for label-free imaging of microarrays of biomolecules upon solid substrates. We demonstrate that hybridization reactions in an oligonucleotide microarray fabricated upon a glass slide can be detected by such an OI-RD microscope.

Original languageEnglish (US)
Pages (from-to)581-583
Number of pages3
JournalOptics Letters
Volume29
Issue number6
StatePublished - Mar 15 2004

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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