Label-free biochemical characterization of stem cells using vibrational spectroscopy

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76 Scopus citations


Raman and infrared (IR) spectroscopy are two complementary vibrational spectroscopic techniques that have experienced a tremendous growth in their use in biological and biomedical research. This is, in large part, due to their unique capability of providing label-free intrinsic chemical information of living biological samples at tissue, cellular, or sub-cellular resolutions. This article reviews recent developments in applying these techniques for the characterization of stem cells. A discussion of the potential for these methods to address some of the major challenges in stem cell research is presented, as well as the technological and scientific advancements that are needed to progress the knowledge in the field.

Original languageEnglish (US)
Pages (from-to)656-668
Number of pages13
JournalJournal of Biophotonics
Issue number11
StatePublished - Nov 2009


  • Adult stem cells
  • Embryonic stem cells
  • Infrared spectroscopy
  • Mesenchymal stem cells
  • Raman spectroscopy

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)
  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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